Tobey Maguire в ролята на Peter Parker / Spider-Man
Kirsten Dunst в ролята на Mary Jane Watson
James Franco в ролята на Harry Osborn
Alfred Molina в ролята на Otto Octavius / Doctor Octopus
Rosemary Harris в ролята на May Parker
J.K. Simmons в ролята на J. Jonah Jameson
Donna Murphy в ролята на Rosalie Octavius
Dylan Baker в ролята на Dr. Curt Connors
Daniel Gillies в ролята на John Jameson
Bill Nunn в ролята на Joseph 'Robbie' Robertson
Vanessa Ferlito в ролята на Louise
Aasif Mandvi в ролята на Mr. Aziz
Willem Dafoe в ролята на Norman Osborn
Cliff Robertson в ролята на Ben Parker
Ted Raimi в ролята на Hoffman
Elizabeth Banks в ролята на Miss Brant
Bruce Campbell в ролята на Snooty Usher
Gregg Edelman в ролята на Dr. Davis
Elya Baskin в ролята на Mr. Ditkovich
Mageina Tovah в ролята на Ursula
Daniel Dae Kim в ролята на Raymond
Hal Sparks в ролята на Elevator Passenger (uncredited)
Joel McHale в ролята на Mr. Jacks
Stan Lee в ролята на Man Dodging Debris (uncredited)
Kelly Connell в ролята на Dr. Isaacs
Brent Briscoe в ролята на Garbage Man (uncredited)
Emily Deschanel в ролята на Receptionist (uncredited)
Jason Fiore-Ortiz в ролята на Henry Jackson
Scott Spiegel в ролята на Man on Balcony (uncredited)
Andy Bale в ролята на OsCorp Executive
Christine Estabrook в ролята на Mrs. Jameson
Molly Cheek в ролята на Society Woman (uncredited)
John Paxton в ролята на Houseman (uncredited)
Joy Bryant в ролята на Woman at Web (uncredited)
Joanne Baron в ролята на Skeptical Scientist (uncredited)
Peter McRobbie в ролята на OsCorp Representative (uncredited)
Timothy Jerome в ролята на Injured Scientist (uncredited)
Taylor Gilbert в ролята на Mrs. Watson (uncredited)
Peter Vouras в ролята на Stage Manager (uncredited)
Donnell Rawlings в ролята на Pizza 'Heist' Witness (uncredited)
Zachry Rogers в ролята на Boy Saved by Spider-Man (uncredited)
Ella Rogers в ролята на Girl Saved by Spider-Man (uncredited)
Louis Lombardi в ролята на Poker Player (uncredited)
Marc John Jefferies в ролята на Amazed Kid (uncredited)
Roshon Fegan в ролята на Amazed Kid (uncredited)
Brendan Patrick Connor в ролята на Theater Traffic Cop (uncredited)
Reed Diamond в ролята на Algernon (uncredited)
Dan Callahan в ролята на Jack (uncredited)
Elyse Dinh в ролята на Violinist (uncredited)
John Landis в ролята на Doctor (uncredited)
Tim Storms в ролята на Chainsaw Doctor (uncredited)
Susie Park в ролята на Clawing Nurse (uncredited)
Tricia Peters в ролята на Screaming Nurse (uncredited)
Michael Edward Thomas в ролята на Man at Fire (uncredited)
Anne Betancourt в ролята на Woman at Fire (uncredited)
Venus Lam в ролята на Child in Burning Building (uncredited)
Bill E. Rogers в ролята на Fireman (uncredited)
Joe Virzi в ролята на Fireman (uncredited)
Tom Carey в ролята на Train Conductor (uncredited)
Jopaul Van Epp в ролята на Boy with Mask (uncredited)
Weston Epp в ролята на Boy with Mask (uncredited)
Peter Allas в ролята на Train Passenger (uncredited)
Brianna Brown в ролята на Train Passenger (uncredited)
Bill Calvert в ролята на Train Passenger (uncredited)
Tony Campisi в ролята на Train Passenger (uncredited)
Joey Diaz в ролята на Train Passenger (uncredited)
Chloe Dykstra в ролята на Train Passenger (uncredited)
Simone Gordon в ролята на Train Passenger (uncredited)
Dan Hicks в ролята на Train Passenger (uncredited)
Julia Max в ролята на Train Passenger (uncredited)
Savannah Pope в ролята на Train Passenger (uncredited)
Timothy Patrick Quill в ролята на Train Passenger (uncredited)
Jill Sayre в ролята на Train Passenger (uncredited)
Rickey G. Williams в ролята на Train Passenger (uncredited)
Michael Arthur в ролята на NYPD Officer (uncredited)
Frank Bonsangue в ролята на Pizza Man (uncredited)
Cindy Cheung в ролята на Chinese Daughter (uncredited)
Phil LaMarr в ролята на Train Passenger (uncredited)
Calvin Dean в ролята на Boomer (uncredited)
Andre M. Johnson в ролята на Fireman 2 (uncredited)
Peter Cincotti в ролята на Piano Player in Planetarium (uncredited)
Peyton List в ролята на Little Girl Playing on Steps (uncredited)
Spencer List в ролята на Little Boy Playing on Steps (uncredited)
Troy Metcalf в ролята на Blue Collar Guy (uncredited)
Scott Ross в ролята на Pedestrian (uncredited)
Bonnie Somerville в ролята на Screaming Woman (uncredited)
Wesley Volcy в ролята на Columbia University Student (uncredited)
Lou Volpe в ролята на Man at Web (uncredited)
Garrett Warren в ролята на Bearded Doctor (uncredited)
