Will Smith character Capt. James West
Kevin Kline character U.S. Marshal Artemus Gordon / President Grant
Kenneth Branagh character Dr. Arliss Loveless
Salma Hayek character Rita Escobar
M. Emmet Walsh character Coleman
Ted Levine character General 'Bloodbath' McGrath
Frederique van der Wal character Amazonia
Musetta Vander character Munitia
Sofia Eng character Miss Lippenrieder
Garcelle Beauvais character Belle
Bai Ling character Miss East
Rodney A. Grant character Hudson
E.J. Callahan character Mr. Pinkerton
Debra Christofferson character Dora Look-Alike
Buck Taylor character Cross-Eyed Reb
James Lashly character Reb #1
Dean Rader Duval character Reb #2
Jerry Wills character Other Reb
Mike H. McGaughy character Big reb
Christian Aubert character French Dignitary
Orestes Matacena character Spanish Dignitary
Ian Abercrombie character British Dignitary
Ismael "East" Carlo character Mexican Dignitary
Bob Rumnock character White House Aide
Gary Carlos Cervantes character Dr. Guillermo Escobar
Jerry Potter character George Washington
Mik Scriba character Guard
Michael Sims character Prof. Thaddeus Morton
Natalie Fabry character Little Girl (uncredited)