Kenneth Branagh character Franklin Delano Roosevelt
Cynthia Nixon character Eleanor Roosevelt
David Paymer character Louis Howe
Tim Blake Nelson character Tom Loyless
Matt O'Leary character Fred Botts
Matt Malloy character Lionel Purdy
Andy Davoli character Jake Perini
Nelsan Ellis character Roy Collier
Jane Alexander character Sara Delano Roosevelt
Kathy Bates character Helena Mahoney
Melissa Ponzio character Lucy Mercer
Quint Von Canon character Stephen Teller
Mike Pniewski character Hastings
Grayce Spence character League Member
Rand Hopkins character Dr. Lovett
Brian F. Durkin character Elliott Roosevelt
Carrie Adams character Anna - Age 19
Georgia Miles character Anna - Age 12
Devon Gearhart character Elliot - Age 8 and 11
Tripp Hennington character Franklin Junior - Age 9
Sam Frihart character John - Age 7
Matthew Stanton character Scoutmaster
Ron Clinton Smith character Eugene
Lonnie R. Smith Jr. character Stanley
Jill Jane Clements character Waitress
Dave Hager character Pat Doyle
Felicia Day character Eloise Hutchinson
Meggie Geisland character Daisy
E. Roger Mitchell character Pete Collier
Deborah Duke character Aunt Sally
Bob Seel character Cleburne Gregory
Brian Beegle character Benjamin Pendergrast
Steve Coulter character Dr. Bissell
Marianne Fraulo character Missy Lehand
Jody Thompson character Woodhall Busey
Frank Hoyt Taylor character Conductor
Lori Beth Sikes character Mary Beth
Teal Sherer character Chorus Girl #1
Margo G. Dietrich character Chorus Girl #2
Laurel Lawson character Chorus Girl #3
Danny Nelson character Farmer
Sharon Blackwood character Farmer's Wife
Bart Hansard character Stationmaster at Bullochsville
Terry Loughlin character Dr. Peter Hebert
Marc McPherson character Dr. Willis
J.L. Parker character Helena's Driver
Wilbur Fitzgerald character Al Smith
Terrence Gibney character Crony #1
David Silverman character Crony #2
Robert C. Treveiler character Dan Reed
Carl McIntyre character Reporter
Greg Thompson character Photographer
Ron Goss character Convention Announcer