Joaquin Phoenix character Larry "Doc" Sportello
Josh Brolin character Lt. Det. Christian F. "Bigfoot" Bjornsen
Owen Wilson character Coy Harlingen
Katherine Waterston character Shasta Fay Hepworth
Reese Witherspoon character Deputy D.A. Penny Kimball
Benicio del Toro character Sauncho Smilax
Jena Malone character Hope Harlingen
Maya Rudolph character Petunia Leeway
Martin Short character Dr. Rudy Blatnoyd, D.D.S.
Martin Donovan character Crocker Fenway
Sasha Pieterse character Japonica Fenway
Eric Roberts character Michael Z. Wolfmann
Michael Kenneth Williams character Tariq Khalil
Joanna Newsom character Sortilège
Jeannie Berlin character Aunt Reet
Serena Scott Thomas character Sloane Wolfmann
Hong Chau character Jade
Christopher Allen Nelson character Glenn Charlock
Sam Jaeger character Agent Flatweed
Timothy Simons character Agent Borderline
Jillian Bell character Chlorinda
Jordan Christian Hearn character Denis
Taylor Bonin character Ensenada Slim
Martin Dew character Dr. Buddy Tubeside
Shannon Collis character Bambi
Catherine Haena Kim character News Reporter
Vivienne Khaledi character Amethyst Harlingen
Yvette Yates Redick character Luz
Andrew Simpson character Riggs Warbling
Joe Dioletto character Cop with Bigfoot
Jack Kelly character Burke Stodger (archive footage)
Belladonna character Clancy Charlock
Elaine Tan character Xandra
Wilson Bethel character LAPD Officer #1
Anders Holm character LAPD Officer #2
Emmet Unverzagt character Bigfoot's Kid
Erica Sullivan character Dr. Lily Hammer
Eva Fisher character Dr. Threeply's Assistant #1
Jackie Michele Johnson character Dr. Threeply's Assistant #2
Katie Schwartz character Kimberly
Charley Morgan character Dr. Igor
Keith Jardine character Puck Beaverton
Delaina Mitchell character Mrs. Chastity Bjornsen
Michael Cotterman character Rhus Frothingham
Peter McRobbie character Adrian Prussia
Shannon C. Sullivan character Adrian Prussia's Secretary
Samantha Lemole character Golden Fang Mother
Madison Leisle character Golden Fang Daughter
Christian Williams character Smedley
Jefferson Mays character Dr. Threeply
Liam Van Joosten character Golden Fang Son
Matt Doyle character Golden Fang Father
Ashleigh Biller character Patient (uncredited)
David Prak character Buddhist Monk
Amy Ferguson character Bodhi
Emma Dumont character Zinnia
Scott Aschenbrenner character Jesus Guard (uncredited)
Christina Bobrowsky character Patient (uncredited)
Peter Bonilla character Police Officer (uncredited)
Gregoer Boru character Recording Tech (uncredited)
Marianne Bourg character Beach Girl (uncredited)
Toyia Brown character Harmony (uncredited)
Stu Brumbaugh character Groupie (uncredited)
Seth Cash character Detective (uncredited)
Laura Lyon Rossi character Groupie (uncredited)
Elizabeth Colunga character Patient (uncredited)
Emma Cooper character Groupie (uncredited)
Nick de Graffenreid character Patient (uncredited)
Adam Dorsey character Jesus Guard (uncredited)
Ken Edling character Judge (uncredited)
Jenna Emery character Groupie (uncredited)
Al Function character Biker (uncredited)
Brandy Futch character Flight Attendant (uncredited)
Lauren Goncher character Dental Assistant (uncredited)
Ellen Ho character Chinese Waitress (uncredited)
Jessica Huss character Speed Freak (uncredited)
Raiden Integra character Patient (uncredited)
Dallas James character Auto Mechanic (uncredited)
Christopher Karl Johnson character Mr. Robinson (uncredited)
Laura Kranz character Chryskylodon Patient (uncredited)
Timothy Lally character Commando (uncredited)
Adeana Lane character Beach Girl (uncredited)
Kira Legg character Groupie (uncredited)
Tracy Ann Lisa character District Attorney (uncredited)
Blue LoLan character Patient (uncredited)
Jacob Lyman character Mormon FBI Agent (uncredited)
Amanda Maddox character Flight Attendant (uncredited)
Emilee Madrak character Groupie (uncredited)
Kirstin Masters character Dental Assistant (uncredited)
Zach McMahon character Police Officer (uncredited)
Chelsea O'Toole character Patient (uncredited)
Shaun Parker character Commando (uncredited)
Rodney J. Richards character Adrian Prussia's Friend (uncredited)
Philip Roosevelt character Hippie in Commune (uncredited)
Osamu Saito character Japanese Waiter (uncredited)
Joel Shock character Police Officer (uncredited)
Matthew Skomo character Detective (uncredited)
Chantal Thuy character Groupie (uncredited)
Diana Elizabeth Torres character Lourdes (uncredited)
