Ed Helms character Rusty Griswold
Christina Applegate character Debbie Griswold
Skyler Gisondo character James Griswold
Chevy Chase character Clark Griswold
Charlie Day character Chad
Miles Doleac character Man on the Monument
Chris Hemsworth character Stone Crandall
Leslie Mann character Audrey Griswold
Steele Stebbins character Kevin Griswold
Beverly D'Angelo character Ellen Griswold
Catherine Missal character Adena
Ron Livingston character Ethan
Norman Reedus character Trucker
Elizabeth Gillies character Heather
Keegan-Michael Key character Jack Peterson
Regina Hall character Nancy Peterson
Nadine Avola character Chelsea
Brandon Michael Hale character Gas Station Clerk
Nick Kroll character Colorado Cop
Tim Heidecker character Utah Cop
Kaitlin Olson character Arizona Cop
Michael Peña character New Mexico Cop
Colin Hanks character Jake
Emyri Crutchfield character Sheila Peterson
Alkoya Brunson character Gary Peterson
Hannah Davis character Ferrari Girl
David Clennon character Harry Co-Pilot
Kirstin Ford character Mom on Plane
Ethan Maher character Boy on Plane
Cristina Squyres character Brooke
Ryan Cartwright character Terry
Valerie Payton character Shuttle Driver
O'Clair Alexander character Husky Lady at Monument
Holly Gardner character Women at Monument
R.F. Daley character Furious Husband
Elizabeth Fendrick character Furious Wife
Michael H. Cole character Male Guest
Brooke Jaye Taylor character Female Guest
Matthew Cornwell character Male Guest #2
John Francis Daley character Ride Operator
Libby Blanton character Boobs
Rick Ericson character Hawaiian
Omar Lagudali character Reporter
Cameron McIntyre character Young James (age 7 / 9)
