David Duchovny character Mike Klein
Sigourney Weaver character Lenny
Ioan Gruffudd character Richard McCallister
Judy Greer character Alice
Fran Kranz character Zach Harper
Lindsay Sloane character Laurel Simon
Justine Bateman character Natalie Klein
Lucy Davis character Chloe McCallister
Willie Garson character Brian
M.C. Gainey character Hutch
Simon Helberg character TJ Goldman
Philip Baker Hall character Vernon Maxwell
Nat Faxon character Reporter
Jonathan Silverman character Himself
Bree Turner character Carla
Seth Green character Himself
Kathryn Joosten character Lois
Allison Scagliotti character Bethany
Marcia Moran character Casting Director
Andrea Martin character Becky
