James Cagney character Tom Powers
Jean Harlow character Gwen Allen
Edward Woods character Matt Doyle
Joan Blondell character Mamie
Donald Cook character Mike Powers
Leslie Fenton character Samuel 'Nails' Nathan
Beryl Mercer character Ma Powers
Robert Emmett O'Connor character Paddy Ryan
Murray Kinnell character Putty Nose
Clark Burroughs character Dutch (uncredited)
Mae Clarke character Kitty (uncredited)
Frank Coghlan Jr. character Tom as a Boy (uncredited)
George Daly character Machine Gunner (uncredited)
Frankie Darro character Matt as a Boy (uncredited)
Snitz Edwards character Miller (uncredited)
Rita Flynn character Molly Doyle (uncredited)
Dorothy Gee character Nails' Girl (uncredited)
Douglas Gerrard character Assistant Tailor (uncredited)
Dorothy Gray character Little Girl (uncredited)
Ben Hendricks Jr. character 'Bugs' Moran as a Boy (uncredited)
Robert Homans character Officer Pat Burke (uncredited)
Eddie Kane character Joe - Headwaiter (uncredited)
Mia Marvin character Jane (uncredited)
Sam McDaniel character Headwaiter (uncredited)
Helen Parrish character Little Girl (uncredited)
Lee Phelps character Steve - Bartender (uncredited)
Russ Powell character Bartender (uncredited)
Purnell Pratt character Officer Powers (uncredited)
Nanci Price character Little Girl (uncredited)
Joe Sawyer character Pool Player (uncredited)
Landers Stevens character Doctor (uncredited)
William H. Strauss character Pawnbroker (uncredited)
Charles Sullivan character Mug (uncredited)
Lucille Ward character Mrs. Dalton (uncredited)
Adele Watson character Mrs. Doyle (uncredited)