Claude Rains character Jack "The Invisible Man" Griffin
Gloria Stuart character Flora Cranley
William Harrigan character Arthur Kemp
Henry Travers character Dr. Cranley
Una O'Connor character Jenny Hall
Forrester Harvey character Herbert Hall
Holmes Herbert character Chief of Police
E. E. Clive character Constable Jaffers
Dudley Digges character Chief Detective
Harry Stubbs character Inspector Bird
Donald Stuart character Inspector Lane
Merle Tottenham character Millie
Walter Brennan character Bicycle Owner (uncredited)
John Carradine character Informer Suggesting Ink (uncredited)
Dwight Frye character Reporter (uncredited)
Mary Gordon character Screaming Woman (uncredited)
Crauford Kent character Doctor (uncredited)
Paul Kruger character Constable (uncredited)
Monte Montague character Cop (uncredited)
Jack Montgomery character Constable (uncredited)
Charles Morton character Party Guest (uncredited)
Tom Ricketts character Old Farmer with Barn (uncredited)
Jameson Thomas character Hospital Doctor (uncredited)
Bert Young character Railroad Switchman (uncredited)
Violet Kemble Cooper character Woman (uncredited)