Diego Luna character Manolo (voice)
Channing Tatum character Joaquin (voice)
Zoe Saldana character Maria (voice)
Christina Applegate character Mary Beth (voice)
Eugenio Derbez character Chato (voice)
Cheech Marin character Pancho Rodriguez (voice)
Gabriel Iglesias character Pepe Rodriguez (voice)
Ron Perlman character Xibalba (voice)
Kate del Castillo character La Muerte (voice)
Ana de la Reguera character Carmen Sánchez (voice)
Dan Navarro character Chakal (voice)
Ice Cube character Candle Maker (voice)
Héctor Elizondo character Carlos Sanchez (voice)
Danny Trejo character Skeleton Luis (voice)
Carlos Alazraqui character General Posada / Dali / Chuy (voice)
Emil-Bastien Bouffard character Young Manolo (voice)
Elijah Rodriguez character Young Joaquin
Genesis Ochoa character Young Maria (voice)
Plácido Domingo character Skeleton Jorge (voice)
Grey DeLisle character Grandmother (voice) (as Grey Griffin)
Trey Bumpass character Goth Kid / Orphan
Miguel Sandoval character Land of the Remembered Captain (voice)
Ben Gleib character Goya / Dali (voice)
Ricardo El Mandril Sanchez character Pablo Rodriguez (voice)
Ishan Sharma character Sanjay
Jorge R. Gutierrez character Skeleton Carmelo (voice)
Anjelah Johnson-Reyes character Adelita / Nina (voice)
Kennedy Peil character Sasha (voice)
Sandra Equihua character Scardelita (voice)
Callahan Clark character Jane (voice)
Gunnar Sizemore character Ignacio (voice)
Angélica María character Sister Ana (voice)
Eric Bauza character Father Domingo / Cave Guardian (voice)
Aron Warner character Thomas (voice)
Sandra Echeverría character Claudia (voice)
Tonita Castro character La Muerte as Old Woman (voice)
Troy Evans character Old Man Hemingway (voice)
Guillermo del Toro character Land of the Remembered Captain's Wife (voice)
Brad Booker character Conductor (voice)
Rosemary Alexander character Additional Voices (voice)
Steve Alterman character Additional Voices (voice)
Eva Bella character Additional Voices (voice)
Madison Carlon character Additional Voices (voice)
Vicki Davis character Additional Voices (voice)
Moosie Drier character Additional Voices (voice)
Maximilian Ehrenreich character Manolo (voice)
Cullen McCarthy character Additional Voices (voice)
David Michie character Additional Voices (voice)
Michelle Moores character Additional Voices (voice)
Jonathan Nichols character Additional Voices (voice)
Al Rodrigo character Additional Voices (voice)
Marcelo Tubert character Additional Voices (voice)
Lynnanne Zager character Additional Voices (voice)
Ruth Zalduondo character Additional Voices (voice)
Newell Alexander character Additional Voices (voice)
Jose Alvarez character Additional Voices (voice)
David Cowgill character Additional Voices (voice)
Elisa Gabrielli character Additional Voices (voice)
Richard Miro character Additional Voices (voice)
Arthur Ortiz character Additional Voices (voice)
Nathaniel Semsen character Additional Voices (voice)
