Brad Pitt character Jesse James
Casey Affleck character Robert Ford
Sam Rockwell character Charley Ford
Sam Shepard character Frank James
Mary-Louise Parker character Zee James
Paul Schneider character Dick Liddil
Jeremy Renner character Wood Hite
Garret Dillahunt character Ed Miller
Zooey Deschanel character Dorothy Evans
Michael Parks character Henry Craig
Ted Levine character Sheriff Timberlake
Brooklynn Proulx character Mary James
Dustin Bollinger character Tim James
Joel McNichol character Express Messenger
James Defelice character Baggagemaster
J.C. Roberts character Engineer
Darrell Orydzuk character Ukrainian Train Passenger
Jonathan Erich Drachenberg character Young Train Passenger
Torben S. Hansen character Danish Train Passenger
Alison Elliott character Martha Bolton
Lauren Calvert character Ida
Kailin See character Sarah Hite
Tom Aldredge character Major George Hite
Jesse Frechette character Albert Ford
Pat Healy character Wilbur Ford
Joel Duncan character Deputy
James Carville character Governor Crittenden
Stephanie Wahlstrom character Store Customer
Adam Arlukiewicz character Newsboy
Ian Ferrier character Photographer
Calvin Bliid character Small Boy at Jesse's Death
Sarah Lind character Bob's Girlfriend
Nick Cave character Bowery Saloon Singer
Michael Copeman character Edward O'Kelly
Laryssa Yanchak character Ella Mae Waterson
Anthony Harrison character Marshal Craig (uncredited)
Hugh Ross character Narrator (voice)
