Teresa Wright character Charlotte 'Charlie' Newton
Joseph Cotten character Uncle Charlie Oakley
Macdonald Carey character Jack Graham
Henry Travers character Joseph Newton
Patricia Collinge character Emma Newton
Hume Cronyn character Herbie Hawkins
Wallace Ford character Fred Saunders
Edna May Wonacott character Ann Newton
Charles Bates character Roger Newton
Irving Bacon character Station Master
Clarence Muse character Pullman Porter
Janet Shaw character Waitress Louise Finch
Estelle Jewell character Catherine
Virginia Brissac character Mrs. Phillips (uncredited)
Frances Carson character Mrs. Potter (uncredited)
Earle S. Dewey character Mr. Norton - Traffic Cop (uncredited)
Sarah Edwards character Doctor's Wife on Train (uncredited)
Edward Fielding character Doctor on Train (uncredited)
Vaughan Glaser character Dr. Phillips (uncredited)
Alfred Hitchcock character Man on Train Playing Cards (uncredited)
Shep Houghton character Ballroom Dancer (uncredited)
Ruth Lee character Mrs. MacCurdy (uncredited)
Eily Malyon character Mrs. Cochran - Librarian (uncredited)
John McGuire character Teen at Crosswalk (uncredited)
Shirley Mills character Shirley (uncredited)
Constance Purdy character Mrs. Martin - Landlady (uncredited)
Isabel Randolph character Margaret Green (uncredited)
Grandon Rhodes character Rev. MacCurdy (uncredited)
Byron Shores character Detective (uncredited)
Edwin Stanley character Mr. Green - Bank President (uncredited)
Minerva Urecal character Mrs. Henderson - Clerk at Telegraph Office (uncredited)