James McAvoy character Patricia / Dennis / Hedwig / The Beast / Barry / Heinrich / Jade / Ian / Mary Reynolds / Norma / Jalin / Kat / B.T. / Kevin Wendell Crumb / Mr. Pritchard / Felida / Luke / Goddard / Samuel / Polly
Bruce Willis character David Dunn / The Overseer
Anya Taylor-Joy character Casey Cooke
Sarah Paulson character Dr. Ellie Staple
Samuel L. Jackson character Elijah Price / Mr. Glass
William Turner character Young Elijah
Johnny Hiram Jamison character 13-Year-Old Elijah
Owen Vitullo character 8-Year-Old Kevin
Colin Becker character 10-Year-Old David
Spencer Treat Clark character Joseph Dunn
Charlayne Woodard character Mrs. Price
Luke Kirby character Pierce
Adam David Thompson character Daryl
M. Night Shyamalan character Jai
Shannon Destiny Ryan character Cheerleading Girl #1
Diana Silvers character Cheerleading Girl #2
Nina Wisner character Cheerleading Girl #3
Kyli Zion character Cheerleading Girl #4
Rosemary Howard character Penelope Crumb
Bryan McElroy character Clarence Crumb
Serge Didenko character Ronald, Powerful Young Man
Russell Posner character T, Skinny Camera Kid
Kimberly S. Fairbanks character Assistant Principal
Leslie Stefanson character Woman on Train
Marc H. Glick character Train Engineer
Brick Mason character Carnival Barker
Bostin Christopher character Comic Book Counter Guy
Ukee Washington character News Anchor
Brian Anthony Wilson character Security Guard in Car
Tobias Segal character Surveillance Security Guard
Joseph Thuet character Joe, Security Guard
Tatiana St. Phard character Woman Group Member
Tom DiNardo character Homeless Person
Timothy Chivalette character Comic Book Geek #1
Jack McCafferty character Comic Book Geek #2
Darby Schlosser character Foster Sibling #1
Jordan Coker character Foster Sibling #2
Emma Hong character Foster Sibling #3
Xaiver Gerald character Foster Sibling #4
Tim Duquette character Patient Jimmy
Nathan Nauroth character Orderly Harrison
Ana Leonard character Hospital Volunteer
Brad William Henke character (archive footage)
Betty Buckley character (archive footage)
Jessica Sula character (archive footage)
