Tobey Maguire character Peter Parker / Spider-Man
Kirsten Dunst character Mary Jane Watson
James Franco character Harry Osborn / New Goblin
Thomas Haden Church character Flint Marko / Sandman
Topher Grace character Eddie Brock / Venom
Bryce Dallas Howard character Gwen Stacy
Dylan Baker character Curt Connors
Rosemary Harris character May Parker
J.K. Simmons character J. Jonah Jameson
James Cromwell character Captain Stacey
Theresa Russell character Mrs. Marko
Bill Nunn character Joseph Robertson
Bruce Campbell character Maître D'
Elizabeth Banks character Miss Brant
Ted Raimi character Hoffman
Perla Haney-Jardine character Penny Marko
Willem Dafoe character Norman Osborn / Green Goblin
Cliff Robertson character Ben Parker
Elya Baskin character Mr. Ditkovitch
Mageina Tovah character Ursula
John Paxton character Houseman
Becky Ann Baker character Mrs. Stacy
Stan Lee character Man in Times Square
Michael Papajohn character Dennis Carradine / Carjacker
Joe Manganiello character Flash Thompson
Hal Fishman character Anchorman
Lucy Gordon character Jennifer Dugan
Steve Valentine character Photographer
Tim Maculan character Play Director
Marc Vann character Play Producer
Joe Bays character Jazz Club Manager
Gregg Daniel character Precinct Detective
Rogelio T. Ramos character Emergency Room Doctor
Timothy Patrick Quill character Crane Operator
Christopher Young character Pianist
Grant Curtis character Driver
Toni Wynne character Congratulatory Woman at Daily Bugle
Andre B. Blake character Crane Disaster Radio Policeman
Kathryn Bryding character Woman Outside Theater
Joe Virzi character Police Detective
Bill E. Rogers character New Jersey State Policeman
Michael Alexander character New Jersey State Policeman
April Parker-Jones character Test Site Technician
Edward Padilla character Test Site Technician
Robert Curtis Brown character Test Site Technician
Paul Terrell Clayton character Test Site Technician
Carolyn Neff character Test Site Technician
Christina Cindrich character Test Site Technician
Sonya Maddox character ICU Nurse
Derrick 'Phoenix' Thomas character Cop at Crane Disaster
Jessi Collins character Mary Jane's Replacement
Michael McLaughlin character Boy at Key to the City Ceremony
Anne Gartlan character Councilwoman
Emilio Rivera character Policeman at Sand Truck
Keith Woulard character Policeman at Sand Truck
Reynaldo Gallegos character Armored Car Driver
Jim Coope character Newstand Patron
Dean Edwards character Newstand Patron
Margaret Laney character Newstand Patron
Aimee Miles character Coffee Shop Waitress
Tanya Bond character Jazz Club Waitress
Mark Kubr character Jazz Club Bouncer
Tony Besson character Photoshoot Client
Ramon Adams character Businessman (uncredited)
A.J. Adelman character Theater Attendee (uncredited)
Angelis Alexandris character Pedestrian (uncredited)
Dawn Marie Anderson character I.C.U Nurse (uncredited)
Frank Anello character NYPD Officer (uncredited)
Anya Avaeva character Model (uncredited)
David Backus character Bucket Boy (uncredited)
Tiffany L. Baker character News Reporter (uncredited)
Sujeilee Candele character Rescued Girl (uncredited)
Michael Ciesla character Photographer (uncredited)
Irina Costa character Jazz Club Waitress (uncredited)
John Crann character Theater Patron (uncredited)
Crystal Marie Denha character Jazz Club Girl (uncredited)
Amy V. Dewhurst character Columbia Grad Student (uncredited)
Paul Edney character New York City Commuter / Driver (uncredited)
Natalie Fabry character Girl at Key Ceremony (uncredited)
Keith Fausnaught character Pedestrian (uncredited)
Shaun Patrick Flynn character Businessman (uncredited)
Logan Fry character Automobile Driver (uncredited)
Kevin Fung character Spectator (uncredited)
Tony Galtieri character News Spectator (uncredited)
Chuck Gerena character Funeral Limo Driver (uncredited)
Brian Hopson character News Reporter (uncredited)
Claude Jay character Cop (uncredited)
Julie Jei character Female New Yorker (uncredited)
Andrew James Jones character Jazz Club Bouncer (uncredited)
Natalie Jones character Girl at Key Ceremony (uncredited)
Christopher Jude character Student (uncredited)
Brittany Krall character ER Nurse (uncredited)
Alyssa Lakota character Dog Walker (uncredited)
Pierangeli Llinas character Woman in Court (uncredited)
Bernadette Lords character British Publicist (uncredited)
Sandrine Marlier character Shocked Pedestrian (uncredited)
Laura McDavid character Journalist (uncredited)
Natalie McNeil character Girl Screaming in Camaro (uncredited)
Daniel Mignault character Kid in Times Square (uncredited)
Martha Millan character Oscorp Receptionist (uncredited)
Michele-Nanette Miller character Girl in Times Square (uncredited)
Claudia Katz Minnick character Robbie's Assistant (uncredited)
Robert Myers character Theatergoer (uncredited)
Jen Oda character Beautiful Girl (uncredited)
Anjelia Pelay character Beautiful Woman (uncredited)
Nick Poltoranin character Police Officer (uncredited)
Vanessa Reseland character Beautiful Woman (uncredited)
La Rivers character Beautiful Woman (uncredited)
Bria Roberts character Businesswoman (uncredited)
Vanessa Ross character Sandman Victim (uncredited)
Brenna Roth character Bad Girl (uncredited)
Shade Rupe character City Hall Cheerer (uncredited)
Arick Salmea character Guy with Ticket (uncredited)
Eric Shackelford character Jazz Club Beatnik (uncredited)
Daniel Shafer character Jazz Club Guest (uncredited)
Abbey Skinner character Café Girl (uncredited)
Kristin Somo character Jazz Club Patron (uncredited)
Jennifer Sparks character Jazz Club Waitress (uncredited)
Christopher Stadulis character Firefighter (uncredited)
Arne Starr character Broadway Audience Member (uncredited)
Liam Stone character Jazz Club Musician (uncredited)
Tajna Tanovic character Girl in Cab (uncredited)
Aija Terauda character Model (uncredited)
Brigid Turner character Hot Girl (uncredited)
Evelyn Vaccaro character Beautiful Woman (uncredited)
Nick Vlassopoulos character Bar Patron #5 (uncredited)
Sincerely A. Ward character Model (uncredited)
Silq Webster character Model (uncredited)
Graig F. Weich character Student (uncredited)
Fredrick Weiss character Restaurant Patron (uncredited)
Jennifer Weston character ER Nurse (uncredited)
Trenton Willey character City Hall Cheerer (uncredited)
Ray Wineteer character Spectator (uncredited)
Emily Eckes character Beautiful Woman (uncredited)
