Tobey Maguire character Peter Parker / Spider-Man
Willem Dafoe character Norman Osborn / Green Goblin
Kirsten Dunst character Mary Jane Watson
James Franco character Harry Osborn
Rosemary Harris character May Parker
J.K. Simmons character J. Jonah Jameson
Cliff Robertson character Ben Parker
Joe Manganiello character Flash Thompson
Bill Nunn character Joseph 'Robbie' Robertson
Michael Papajohn character Carjacker
Elizabeth Banks character Betty Brant
Ron Perkins character Dr. Mendell Stromm
Randy Mario Poffo character Bone Saw McGraw
Octavia Spencer character Check-In Girl
Lucy Lawless character Punk Rock Girl
Bruce Campbell character Ring Announcer
Ted Raimi character Hoffman
Stan Lee character Man in Fair
Macy Gray character Herself
Johnny Trí Nguyễn character Stunts
Robert Kerman character Tugboat Captain
Gerry Becker character Maximilian Fargas
K. K. Dodds character Simkins
Jack Betts character Henry Balkan
Stanley Anderson character General Slocum
Shan Omar Huey character Teacher
John Paxton character Houseman
Jayce Bartok character Subway Guitarist
Sara Ramirez character Cop at Carjacking
Una Damon character Lab Tour Guide
Larry Joshua character Wrestling Promoter
Timothy Patrick Quill character Wrestling Arena Guard
Jason Padgett character Flash's Crony
Evan Arnold character Doctor
Jill Sayre character Nurse
Brad Grunberg character Heckler
Myk Watford character Cop at Fire
Sylva Kelegian character Mother at Fire
Peter Appel character Cabbie
Joseph D'Onofrio character Opinionated Cop
Jim Norton character Surly Truck Driver
Tim DeZarn character Philip Watson
Corey Mendell Parker character Chaperone in Tram
Ashley Edner character Girl in Tram
Alex Black character Boy in Tram
Rick Avery character Cop (uncredited)
Peter Aylward character Colonel (uncredited)
Jillian Clare character Crying Girl in Tram (uncredited)
Chris Coppola character Kyle (uncredited)
Jesse Heiman character Spectator at School Fight (uncredited)
Leroy Patterson character World Unity Festival Attendant (uncredited)
Benny Urquidez character Mugger (uncredited)
Scott L. Schwartz character Screaming Wrestler (uncredited)
Jophery C. Brown character Chef (uncredited)
Brian J. Williams character Young Thug #2 (uncredited)
Jim Ward character Project Coordinator
Taylor Gilbert character Madeline Watson
Deborah Wakeham character Billy's Mom
Bill Calvert character Fireman
Kristen Marie Holly character Young Lady at Fire
Ajay Mehta character Cabbie
Scott Spiegel character Marine Cop
Mark De Alessandro character Cop (uncredited)
Tia Dionne Hodge character Uptown Woman (uncredited)
Loren Janes character Board of Directors Member (uncredited)
Andray Johnson character Balkan's Aide (uncredited)
Martin Pfefferkorn character Thug on 8x10 (uncredited)
Tammi Sutton character Street Vendor (uncredited)
Lindsay Thompson character Mary Jane's Friend (uncredited)
Sean Valla character Boat Light Man (uncredited)
Philip Ng character Diamond District Attendee (uncredited)
Pete Macnamara character Pentagon Officer (uncredited)
Joy Michelle Moore character World's Fair Mom (uncredited)
Lisa Danielle character Bone-ette (uncredited)
Natalie T. Yeo character Bone-ette (uncredited)
Erica D. Porter character Bone-ette (uncredited)
Kristen Davidson character Bone-ette (uncredited)
Sally Levi character Girl on Bus (uncredited)
David Holcomb character Test Pilot (uncredited)
Shane Habberstad character Little Billy (uncredited)
Rachael Bruce character Times Square Child (uncredited)
Mackenzie Bryce character Times Square Child (uncredited)
Julia Barrie character Times Square Child (uncredited)
Maribel González character Lady Dogwalker (uncredited)
Amy Bouril character Office Lady (uncredited)
William Joseph Firth character Boy in Tram (uncredited)
Laura Gray character Tram Group Mother (uncredited)
Joe Virzi character New Yorker on Bridge (uncredited)
Michael Edward Thomas character New Yorker on Bridge (uncredited)
Jeanie Fox character New Yorker on Bridge (uncredited)
Matt Smith character Cop at Hijacking (uncredited)
