Kristen Wiig character Annie Walker
Maya Rudolph character Lillian Donovan
Rose Byrne character Helen Harris
Wendi McLendon-Covey character Rita
Ellie Kemper character Becca
Melissa McCarthy character Megan Price
Chris O'Dowd character Officer Rhodes
Jon Hamm character Ted
Jill Clayburgh character Judy Walker
Rebel Wilson character Brynn
Michael Hitchcock character Don Cholodecki
Tim Heidecker character Douglas Price
Matt Lucas character Gil
Franklyn Ajaye character Mr. Donovan
Lynne Marie Stewart character Mrs. Donovan
Terry Crews character Rodney
Jessica St. Clair character Whitney
Kali Hawk character Kahlua
Andy Buckley character Helen's Husband
Matt Bennett character Helen's Stepson
Nancy Carell character Helen's Tennis Partner
Melanie Hutsell character Carol
Carnie Wilson character Herself
Wendy Wilson character Herself
Chynna Philips character Herself
Joe Nunez character Oscar the Security Guard
Mia Rose Frampton character Jewelry Store Girl
Tom Yi character Jewelry Store Couple
Elaine Kao character Jewelry Store Couple
Mitch Silpa character Flight Attendant Steve
Dana Powell character Flight Attendant Claire
Greg Tuculescu character Kevin
Brian Petsos character Pete
Ben Falcone character Air Marshall Jon
Richard Riehle character Bill Cozbi
Brennan Crewe character Cafe Patron (uncredited)
Suzanne LaChasse character Hostess (uncredited)
Annie Mumolo character Nervous Woman on Plane
