Renée Zellweger character Betty Sizemore
Morgan Freeman character Charlie
Chris Rock character Wesley
Greg Kinnear character Dr. David Ravell/George McCord
Aaron Eckhart character Del Sizemore
Tia Texada character Rosa Hernandez
Crispin Glover character Roy Ostery
Pruitt Taylor Vince character Ballard
Allison Janney character Lyla Branch
Kathleen Wilhoite character Sue Ann Rogers
Elizabeth Mitchell character Chloe Jensen
Susan Barnes character Darlene
Harriet Sansom Harris character Ellen
Sung-Hi Lee character Jasmine
Laird Macintosh character Dr. Lonnie Walsh
Steven Gilborn character Blake
Jenny Gago character Mercedes
Sheila Kelley character Joyce
Matthew Cowles character Merle
Wayne Tippit character Doctor
George Wallace character Grandfather
Lesley Woods character Grandmother
Cynthia Martells character Chief Nurse
Alfonso Freeman character ER Doctor
Kevin Rahm character Friend #1
Steven Culp character Friend #2
Deborah May character Gloria Walsh
Max Murphy character Studio Guard
Tina Smith character Waitress
T.J. Kennedy character Cook
Irene Olga López character Rosa's Mother
Steve Franken character Administrator
Kelwin Hagen character Deputy
Josh Dotson character Parking Valet
Dona Hardy character Woman Patient
José Vásquez character Gang Member
Elaine Corral Kendall character Anchor
Greg Bronson character Diner Patron (uncredited)
Rebeca Cristian character Hospital Patient (uncredited)
Michelle Carmen Gomez character Woman at Bar (uncredited)
Toby Linz character Sue Ann's Son (uncredited)
Hillary Straney character Woman in Hotel (uncredited)
Jenny Wade character Diner Waitress (uncredited)
