Dakota Fanning character Fern Arable
Julia Roberts character Charlotte the Spider (voice)
Steve Buscemi character Templeton the Rat (voice)
John Cleese character Samuel the Sheep (voice)
Oprah Winfrey character Gussy the Goose (voice)
Cedric the Entertainer character Golly the Goose (voice)
Reba McEntire character Betsy the Cow (voice)
Kathy Bates character Bitsy the Cow (voice)
Robert Redford character Ike the Horse (voice)
Thomas Haden Church character Brooks the Crow (voice)
André Benjamin character Elwyn the Crow (voice)
Dominic Scott Kay character Wilbur (voice)
Sam Shepard character Narrator (voice)
Abraham Benrubi character Uncle the Pig (voice)
Kevin Anderson character Mr. Arable
Essie Davis character Mrs. Arable
Siobhan Fallon Hogan character Mrs. Zuckerman
Louis Corbett character Avery
Robyn Arthur character Teacher
Julian O'Donnell character Henry Fussy
Gary Basaraba character Homer Zuckerman
Nate Mooney character Lurvy
Nicholas Bell character Minister
Beau Bridges character Dr. Dorian
Teague Rook character Well Dressed Man
Julia Zemiro character Bystander
Denise Kirby character New Teacher
Robert Plazek character Ball Thrower
Joseph Lotesto character Young Boy
Michael Roland character Mayor
Don Bridges character Announcer
Ian Watkin character Fair Official
Joel McCrary character Sheep Group (voice)
Brian Stepanek character Sheep Group (voice)
Fred Tatasciore character Sheep Group (voice)
Bradley White character Sheep Group (voice)
Maia Kirkpatrick character Joy the Baby Spider (voice)
Jennessa Rose character Aranea the Baby Spider (voice)
Briana Hodge character Nellie the Baby Spider (voice)
Dale Azzopardi character Photographer (uncredited)
Geoff Burgess character Photographer (uncredited)
Ella Scott Lynch character Girl at Fair (uncredited)
Greg Marian character Farmer (uncredited)
Stefano Mazzeo character Fair Member (uncredited)
Elizabeth Saunders character Girl at Fair (uncredited)
