Johnny Depp character Rango (voice)
Isla Fisher character Beans (Voice)
Ned Beatty character Tortoise John (voice)
Bill Nighy character Rattlesnake Jake (voice)
Alfred Molina character Roadkill (Voice)
Abigail Breslin character Priscilla (Voice)
Claudia Black character Angelique (voice)
Timothy Olyphant character The Spirit of the West (voice)
Ray Winstone character Bad Bill (voice)
Stephen Root character Doc / Merrimack / Mr. Snuggles (voice)
Harry Dean Stanton character Balthazar (voice)
Ian Abercrombie character Ambrose (voice)
Gil Birmingham character Wounded Bird (voice)
James Ward Byrkit character Waffles / Gordy / Papa Joad / Cousin Murt / Curlie / Knife Attacker / Rodent Kid (voice)
Blake Clark character Buford (voice)
Keith Campbell character Sod Buster (voice)
Beth Grant character Bonnie (voice)
John Cothran, Jr. character Elgin (voice)
Patrika Darbo character Delilah / Maybelle (voice)
George DelHoyo character Señor Flan - Mariachi Accordion (voice)
Maile Flanagan character Lucky (voice)
Charles Fleischer character Elbows (voice)
Ryan Hurst character Jedidiah (voice)
Vincent Kartheiser character Ezekiel / Lasso Rodent (voice)
Hemky Madera character Chorizo (voice)
Alex Manugian character Spoons (voice)
Mark 'Crash' McCreery character Parsons (voice)
Joe Nunez character Rock-Eye (voice)
Christopher L. Parson character Hazel Moats / Kinski / Stump / Clinker / Lenny / Boseefus /Dirt Kid (voice)
Lew Temple character Furgus / Hitch (voice)
Alanna Ubach character Boo / Cletus / Fresca / Miss Daisy (voice)
Gore Verbinski character Sergeant Turley / Crevice / Slim / Lupe - Mariachi Violin(voice)
Kym Whitley character Melonee (voice)
