Chris Rock character Osmosis Jones (voice)
Laurence Fishburne character Thrax (voice)
David Hyde Pierce character Drix (voice)
Brandy Norwood character Leah (voice)
Bill Murray character Frank Detorre
Molly Shannon character Mrs. Boyd
William Shatner character Mayor Phlegmming (voice)
Ron Howard character Tom Colonic (voice)
Sherry Lynn character (voice)
Mickie McGowan character Additional Character Voice (voice)
Chris Elliott character Bob
Elena Franklin character Shane Detorre
Kid Rock character Kidney Rock
