Cillian Murphy character J. Robert Oppenheimer
Emily Blunt character Kitty Oppenheimer
Matt Damon character Leslie Groves
Robert Downey Jr. character Lewis Strauss
Florence Pugh character Jean Tatlock
Josh Hartnett character Ernest Lawrence
Casey Affleck character Boris Pash
Rami Malek character David Hill
Kenneth Branagh character Niels Bohr
Benny Safdie character Edward Teller
Jason Clarke character Roger Robb
Dylan Arnold character Frank Oppenheimer
Tom Conti character Albert Einstein
James D'Arcy character Patrick Blackett
David Dastmalchian character William Borden
Dane DeHaan character Kenneth Nichols
Alden Ehrenreich character Senate Aide
Tony Goldwyn character Gordon Gray
Jefferson Hall character Haakon Chevalier
David Krumholtz character Isidor Rabi
Matthew Modine character Vannevar Bush
Scott Grimes character Counsel
Kurt Koehler character Thomas Morgan
John Gowans character Ward Evans
Macon Blair character Lloyd Garrison
Harry Groener character Senator McGee
Gregory Jbara character Chairman Magnuson
Ted King character Senator Bartlett
Tim DeKay character Senator Pastore
Steven Houska character Senator Scott
Petrie Willink character Dutch Student
Matthias Schweighöfer character Werner Heisenberg
Alex Wolff character Luis Alvarez
Josh Zuckerman character Rossi Lomanitz
Rory Keane character Hartland Snyder
Michael Angarano character Robert Serber
Emma Dumont character Jackie Oppenheimer
Sadie Stratton character Mary Washburn
Britt Kyle character Barbara Chevalier
Guy Burnet character George Eltenton
Tom Jenkins character Richard Tolman
Louise Lombard character Ruth Tolman
Michael Andrew Baker character Joe Volpe
Jeff Hephner character Congressman
Olli Haaskivi character Edward Condon
David Rysdahl character Donald Hornig
Josh Peck character Kenneth Bainbridge
Jack Quaid character Richard Feynman
Brett DelBuono character Concerned Scientist
Gustaf Skarsgård character Hans Bethe
James Urbaniak character Kurt Gödel
Trond Fausa Aurvåg character George Kistiakowsky
Devon Bostick character Seth Neddermeyer
Danny Deferrari character Enrico Fermi
Christopher Denham character Klaus Fuchs
Jessica Erin Martin character Charlotte Serber
Ronald Auguste character J. Ernest Wilkins
Máté Haumann character Leo Szilard
Olivia Thirlby character Lilli Hornig
Jack Cutmore-Scott character Lyall Johnson
Harrison Gilbertson character Philip Morrison
James Remar character Henry Stimson
Will Roberts character George C. Marshall
Pat Skipper character James Byrnes
Steve Coulter character James Conant
Jeremy John Wells character AAF Officer
Sean Avery character Weatherman
Adam Kroeger character Army Captain
Drew Kenney character Soldier
Bryce Johnson character AAF Officer 2
Flora Nolan character Burn Victim
Kerry Westcott character Laughing Woman
Christina Hogue character Kissing Woman
Clay Bunker character Kissing Man
Tyler Beardsley character Weeping Man
Maria Teresa Zuppetta character Consoling Woman
Kate French character Presidential Aide
Gary Oldman character Harry Truman
Hap Lawrence character Lyndon Johnson
Meg Schimelpfenig character Senator's Assistant (uncredited)