Reese Witherspoon character Susan Murphy / Ginormica (voice)
Seth Rogen character B.O.B. (voice)
Hugh Laurie character Dr. Cockroach Ph.D. (voice)
Will Arnett character The Missing Link (voice)
Kiefer Sutherland character General W.R. Monger (voice)
Rainn Wilson character Gallaxhar (voice)
Paul Rudd character Derek Dietl (voice)
Stephen Colbert character President Hathaway (voice)
Jimmy Kimmel character Insectosaurus (voice)
Julie White character Wendy Murphy (voice)
Jeffrey Tambor character Carl Murphy (voice)
Amy Poehler character Computer (voice)
Ed Helms character News Reporter (voice)
Renée Zellweger character Katie (voice)
Sean Bishop character Private Bullhorn / Helicopter Pilot / Advisor Ortega (voice)
Rich Dietl character Commander / Advisor Smith (voice)
Rob Letterman character Secret Service Man #1 / Lieutenant (voice)
Tom McGrath character Wilson (voice)
Chris Miller character Advisor Cole / Army Commander Jones (voice)
Mike Mitchell character Advisor Wedgie (voice)
Kent Osborne character Technician Jerry (voice)
Latifa Ouaou character Advisor Ouaou / Mrs. Ronson / Female Advisor #2 / Panicked Guest (voice)
Geoffrey Pomeroy character Soldier #4 / Pilot / Soldier #3 / News Technician (voice)
David P. Smith character Soldier #1 / Advisor Jackson (voice)
Lisa Stewart character Bridesmaid Candy (voice)
Conrad Vernon character Advisor Hawk / Advisor Dither / Minister / Secret Service Man #2 / Mama Dietl (voice)
John Krasinski character Cuthbert (voice)
Stephen Kearin character Technician Bee (voice)
