Danny Trejo character Machete
Michelle Rodriguez character Luz
Jessica Alba character Sartana Rivera
Robert De Niro character Senator John McLaughlin
Steven Seagal character Rogelio Torrez
Cheech Marin character Padre Cortez
Lindsay Lohan character April Booth
Don Johnson character Von Jackson
Billy Blair character Von's Henchman
Jeff Fahey character Michael Booth
Shea Whigham character Sniper
Daryl Sabara character Julio
Tom Savini character Osiris Amanpour
Tito Larriva character Culebra Cruzado
Gilbert Trejo character Jorge
Electra Avellan character Nurse Mona
Elise Avellan character Nurse Lisa
Felix Sabates character Doc Felix
Marci Madison character Nurse Fine
Tina Rodriguez character Tristana
Stacy Keach character Doc Franklin
James Parks character Edgar McGraw
Ara Celi character Reporter
Mayra Leal character Chica (Naked Girl)
Tommy Nix character Dishwasher
Alejandro Antonio character Chief
Juan Gabriel Pareja character Rico
Alicia Rachel Marek character June
Roland Ruiz character Luis
Nina Leon character Machete's Wife
Jason Douglas character Patrolman #1
Mitchell Lance Adams character Patrolman 2
Vic Trevino character Federale Officer
