Jean Dujardin character Lucky Luke
Melvil Poupaud character Jesse James
Sylvie Testud character Calamity Jane
Alexandra Lamy character Belle
Michaël Youn character Billy The Kid
Daniel Prévost character Pat Poker
Chloé Jouannet character Eleanor
Jean-François Balmer character Le gouverneur
André Oumansky character President
Gabriel Corrado character Luke's Father
Pompeyo Audivert character Undertaker
Atilio Pozzobón character Barman
Alberto Laiseca character Dick Digger
Mathias Sandor character Young Luke
Carolina Presno character Luke's Mother
Carlos Kaspar character Hank
Mirta Wons character Mrs. Flimsey
Jorge Noya character Mr. Flimsey
Claudio Weppler character Phil Defer
Horacio Marassi character Colonel Mc Straggle
Daniel Campomenosi character Dr. Doxey
Kazuomi Takagi character Ming Li Fu
Luciano Cáceres character Henchman
Joaquín Berthold character Henchman
Martín Kohan character Henchman
Óscar Kramer character Politician
Daniela Catz character Saloon Girl
Bruno Salomone character Jolly Jumper (voice)