Bill Murray character Garfield (voice)
Breckin Meyer character Jon
Jennifer Love Hewitt character Liz
Stephen Tobolowsky character Happy Chapman
Evan Arnold character Wendell
Mark Christopher Lawrence character Christopher Mello
Vanessa Christelle character Miss Ace Hardware
Daamen J. Krall character Announcer
Eve Brent character Mrs. Baker
Bill Hoag character Roy the Lodge Member
Michael Monks character Deputy Hopkins
Mel Rodriguez character Security Officer
Juliette Goglia character Little Girl
Jerry Hauck character Cop
Jimmy Kimmel character Spanky (voice)
Alyson Stoner character Kid Rat (voice)
Debra Messing character Arlene (voice)
Rufus Gifford character Dog Owner #1
Randee Reicher character Dog Owner #2
Ryan McKasson character Dog Owner #3
Susan Moore character Dog Owner #4
Ben Kronen character Older Man
Richard Kind character Dad Rat (voice)
Nick Cannon character Louis (voice)
Brad Garrett character Luca (voice)
Alan Cumming character Persnikitty (voice)
David Eigenberg character Nermal (voice)
