Owen Wilson character Kyle
Ed Helms character Peter
J.K. Simmons character Ronald Hunt
Katt Williams character Hitchhiker
Terry Bradshaw character Himself
Ving Rhames character Rod Hamilton
Christopher Walken character Dr. Tinkler
Glenn Close character Helen Baxter
Katie Aselton character Sarah
Retta character Annie
Harry Shearer character Gene
June Squibb character Mrs. Hunt
Ivan Mallon character Young Peter (uncredited)
Ali Wong character Ali
Robert Jon Mello character Mr. Jensen
Zachary Haven character Ethan
Mary Grill character Katherine
Ann McKenzie character Sheila
Jessica Gomes character Kaylani
Sarah Skeist character Pretty Flight Attendant
Debra Stipe character Karen Bradshaw
Robert Pralgo character Ferrari Owner
Niki Davis character Ferrari Owner's Wife
Donna DuPlantier character ER Doctor
Robert Walker Branchaud character Officer #1
B'nard Lewis character Officer #2
Andrew Wilson character Hotel Desk Clerk
Ryan Cartwright character Liam
Ryan Gaul character Sean
Taylor Treadwell character Kelly
Jack McGee character Kevin O'Callaghan
Jim France character Father McManus
