Tom Hanks character Dr. Henry Goose / Hotel Manager / Isaac Sachs / Dermot Hoggins / Cavendish Look-a-Like Actor / Zachry
Halle Berry character Native Woman / Jocasta Ayrs / Luisa Rey / Indian Party Guest / Ovid / Meronym
Jim Broadbent character Captain Molyneux / Vyvyan Ayrs / Timothy Cavendish / Korean Musician / Prescient 2
Hugo Weaving character Haskell Moore / Tadeusz Kesselring / Bill Smoke / Nurse Noakes / Boardman Mephi / Old Georgie
Jim Sturgess character Adam Ewing / Poor Hotel Guest / Megan's Dad / Highlander / Hae-Joo Chang / Adam / Zachry Brother-in-Law
Bae Doo-na character Tilda / Megan's Mom / Mexican Woman / Sonmi-451 / Sonmi-351 / Sonmi Prostitute
Ben Whishaw character Cabin Boy / Robert Frobisher / Store Clerk / Georgette / Tribesman
James D'Arcy character Young Rufus Sixsmith / Old Rufus Sixsmith / Nurse James / Archivist
Zhou Xun character Talbot / Hotel Manager / Yoona-939 / Rose
Keith David character Kupaka / Joe Napier / An-kor Apis / Prescient
Susan Sarandon character Madame Horrox / Older Ursula / Yusouf Suleiman / Abbess
Hugh Grant character Rev. Giles Horrox / Hotel Heavy / Lloyd Hooks / Denholme Cavendish / Seer Rhee / Kona Chief
David Gyasi character Autua / Lester Rey / Duophsyte
Robert Fyfe character Old Salty Dog / Mr. Meeks / Prescient 1
Martin Wuttke character Mr. Boerhaave / Guard / Leary the Healer
Robin Morrissey character Young Cavendish
Brody Nicholas Lee character Javier Gomez / Jonas / Zachry's Older Nephew
Ian van Temperley character Enforcer
Amanda Walker character Veronica
Ralph Riach character Ernie
Andrew Havill character Mr. Hotchkiss
Tanja de Wendt character Mrs. Hotchkiss
Raevan Lee Hanan character Little Girl with Orison at Papa Song's / Catkin / Zachry Relative
Götz Otto character Groundsman Withers
Niall Greig Fulton character Haskell Moore's Dinner Guest / Mozza Hoggins
Louis Dempsey character Haskell Moore's Dinner Guest / Jarvis Hoggins
Martin Docherty character Haskell Moore's Dinner Guest / Eddie Hoggins
Alistair Petrie character Haskell Moore's Dinner Guest / Musician / Felix Finch / Lascivious Businessman
Zhu Zhu character Megan Sixsmith / 12th Star Clone
Sylvestra Le Touzel character Haskell Moore's Dinner Guest / Nurse Judd / Aide in Slaughtership
Jojo Schöning character Papa Song Punk
Laura Vietzen character Young Ursula
Thomas Kügel character Vater
Marie Rönnebeck character Ursula's Daughter
Ruby Kastner character Young Girl
Emma Werz character Ursula's Granddaughter
Mya-Lecia Naylor character Miro
Korbyn Hawk Hanan character Adam Grandson
Katy Karrenbauer character Axwoman
Dulcie Smart character Ursula's Mother / Herbalist
Anna Holmes character Scientist / Executive
Shaun Lawton character Secretary
Moritz Berg character Porter
Gigi Lee character Zachry Relative
Genevien Lee character Zachry Relative
Cody Benjamin Lee character Zachry Relative
Heike Hanold-Lynch character Ms. Judd Look-a-like
Victor Solé character Mr. Roderick
Kristoffer Fuss character Lead Enforcer
Marco Albrecht character Scan Enforcer
Gary McCormack character Crane Operator
David Mitchell character Union Spy
