Guillaume Canet character Astérix
Gilles Lellouche character Obélix
Vincent Cassel character Jules César
Jonathan Cohen character Graindemaïs
Julie Chen character Princesse Fu Yi
Leanna Chea character Tat Han
Marion Cotillard character Cléopâtre / Bibine
José Garcia character Biopix
Manu Payet character Ri Qi Qi
Ramzy Bedia character Epidemaïs
Bun-hay Mean character Deng Tsin Qin
Linh-Dan Pham character L'Impératrice
Pierre Richard character Panoramix
Gérard Darmon character Le narrateur (voice)
Tran Vu Tran character Prince du Deng
Philippe Katerine character Assurancetourix
Jérôme Commandeur character Abraracourcix
Audrey Lamy character Bonnemine
Franck Gastambide character Le capitaine Barbe-Rouge
Vincent Desagnat character Perfidus
Orelsan character Titanix
Laura Felpin character Carioca
Issa Doumbia character Baba, la vigie des pirates
Thomas VDB character Sinus
Monsieur Fraize character Plexus
Florian Ordonez character Abdelmalix
Olivio Ordonez character Toufix
David Coscas character Radius
Raphaël Carlier character Cubitus
Tatiana Gousseff character Iélosubmarine
Yann Papin character Abribus
Angèle character Falbala
Matthieu Chedid character Remix
Jason Chicandier character Ordralfabétix
Zlatan Ibrahimović character Antivirus
Samuel Hibon character Lapsus
Marc Hoang character Ramoli
Philippe Canet character Agecanonix
Florent Manaudou character Tabascos
Wesley Weigel character Pirate
Sakhone Holaphong character Chinese villager
André Kalmes character Cétautomatix
