Owen Wilson character John Beckwith
Vince Vaughn character Jeremy Grey
Christopher Walken character Secretary William Cleary
Rachel McAdams character Claire Cleary
Isla Fisher character Gloria Cleary
Jane Seymour character Kathleen Cleary
Ellen Albertini Dow character Grandma Mary Cleary
Keir O'Donnell character Todd Cleary
Bradley Cooper character Zachary 'Sack' Lodge
Ron Canada character Randolph
Henry Gibson character Father O'Neil
Dwight Yoakam character Mr. Kroeger
Rebecca De Mornay character Mrs. Kroeger
David Conrad character Trap
Jennifer Alden character Christina Cleary
Geoff Stults character Craig Garthe
Diora Baird character Vivian
Kathryn Joosten character Chazz's Mom
Naureen Zaim character Hindu Woman
Norma Michaels character Old Irish Woman
James Carville character Himself (uncredited)
Will Ferrell character Chazz Reinhold (uncredited)
John McCain character Himself (uncredited)
Lindsay Schoneweis character Woman in Hat (uncredited)
