John C. Reilly character Dewey Cox
Jenna Fischer character Darlene Madison
Raymond J. Barry character Pa Cox
Kristen Wiig character Edith
Tim Meadows character Sam
Harold Ramis character L'Chai'm
Frankie Muniz character Buddy Holly
Chris Parnell character Theo
Margo Martindale character Ma Cox
Matt Besser character Dave
Nat Faxon character Awards Show Stage Manager
Conner Rayburn character Dewey Age 8
Chip Hormess character Nate Cox
Terrence Beasor character Country Doctor
Honeyboy Edwards character Old Bluesman
Gerry Black character Harmonica Player
Aron Johnson character Teenage Band
Jack Donovan Saperstein character Teenage Band
Taylor Hubert character Teenage Band
Christopher Hurt character Teenage Band
Matt Price character MC (Teacher)
John Maynard character Man at Talent Show
E.J. Callahan character Second Man at Talent Show
Rance Howard character Preacher
Craig Robinson character Bobby Shad
Paul Bates character Nightclub Manager
Patrick Faucette character Bad Men Bass Player
Philip Rosenthal character Mazeltov
Martin Starr character Schmendrick
Oscar Dillon character Audience Guy at Nightclub
Jack McBrayer character DJ
Molly C. Quinn character Teen with Pinups
John Ennis character The Big Bopper
Ed Helms character Stage Manager
Jack White character Elvis Presley
Angela Little character Beth Anne
Odette Annable character Reefer Girl
Tyler Nilson character Bert
Deanna Brooks character Hotel Groupie with Dewey
Ian Roberts character Drug Dealer
Steve Bannos character Prison Guard
Willow Geer character Rehab Nurse
David Doty character Rehab Doctor
Jack Kehler character Press Conference Reporter
Gerry Bednob character The Maharishi
David Krumholtz character Schwartzberg
Tim Bagley character Engineer
Jane Lynch character Gail the Television Reporter
Skyler Gisondo character Dewdrop
Kshitij Pendurkar character Dewey Rahim
Simon Helberg character Dreidel L'Chaim
Jacques Slade character Lil' Nutzzak
Danica Rozelle character Music Video Girl
Lurie Poston character Cox Kid
Maggie Mannion character Cox Kid
Jackson Browne character Jackson Browne
Jewel character Jewel
Lyle Lovett character Lyle Lovett
Stacey Scowley character Pierced Eyebrow Girl
Ajla Hodžić character Pierced Lip Girl
Ghostface Killah character Ghostface Killah
Otis Williams character The Temptations
Ron Tyson character The Temptations
Terry Weeks character The Temptations
Joe Herndon character The Temptations
Bruce Williamson character The Temptations
Eddie Vedder character Eddie Vedder
Don Abernathy character Pygmy Bushman / Man in 50's Club (uncredited)
Patrick J. Adams character The Kid (uncredited)
Jack Black character Paul McCartney (uncredited)
Clement Blake character Edith's Father (uncredited)
Patrick Duffy character Patrick Duffy (uncredited)
Morgan Fairchild character Morgan Fairchild (uncredited)
Paul Feig character Different DJ (uncredited)
Amber Hay character LSD Vision (uncredited)
John Michael Higgins character Record Producer (uncredited)
Jonah Hill character Older Nate (uncredited)
Neil Ironfield character Dewey's Child (uncredited)
Cheryl Ladd character Cheryl Ladd (uncredited)
Justin Long character George Harrison (uncredited)
Paul Rudd character John Lennon (uncredited)
Jason Schwartzman character Ringo Starr (uncredited)
Cheryl Tiegs character Cheryl Tiegs (uncredited)
Serria Tawan character 70's African American Woman (uncredited)
