Martin Short character Jack Putter
Dennis Quaid character Lt. Tuck Pendleton
Meg Ryan character Lydia Maxwell
Kevin McCarthy character Victor Eugene Scrimshaw
Fiona Lewis character Dr. Margaret Canker
Vernon Wells character Mr. Igoe
Robert Picardo character The Cowboy
Dick Miller character Cab Driver
Wendy Schaal character Wendy
Harold Sylvester character Pete Blanchard
William Schallert character Dr. Greenbush
Henry Gibson character Mr. Wormwood
John Hora character Ozzie Wexler
Mark L. Taylor character Dr. Niles
Orson Bean character Lydia's Editor
Kevin Hooks character Duane
Kathleen Freeman character Dream Lady
Archie Hahn character Messenger
Kenneth Tobey character Man in Restroom
Joe Flaherty character Waiting Room Patient
Andrea Martin character Waiting Room Patient
Jason Laskay character Scrimshaw's Henchman
Frank Miller character Scrimshaw's Henchman
Christine Avila character Lab Technician
Alexandra Borrie character Lab Technician
Jenny Gago character Lab Technician
Robert Gounley character Lab Technician
Grainger Hines character Rusty
Mike Garibaldi character Cop
Richard McGonagle character Cop
Terence McGovern character Travel Agent
Robert Neches character Lab Guard
Rance Howard character Supermarket Customer
Chuck Jones character Supermarket Customer
Laura Waterbury character Supermarket Customer
Kurt Braunreiter character Lab Assault Henchman
Brewster Sears character Lab Assault Henchman
Alan Blumenfeld character Man with Camera
Jeffrey Boam character Lydia's Interviewee
Sydne Squire character Stewardess
Paul Barselou character Man on Plane
John Miranda character Man in Elevator
Jordan Benjamin character Little Kid in Mall
Roberto Ramirez character Chef
Virginia Boyle character Shopping Lady
Herb Mitchell character Camera Store Clerk
Neil Ross character Pod Computer (voice)
Robert Gray character Lab Assault Henchman
Shawn Nelson character Wendell
Joe Dante character Vectorscope Employee (uncredited)
