Ryan Reynolds character Jerry Hickfang / Mr. Whiskers (voice) / Bosco (voice) / Deer (voice) / Bunny Monkey (voice)
Gemma Arterton character Fiona
Anna Kendrick character Lisa
Jacki Weaver character Dr. Warren
Ella Smith character Alison
Paul Chahidi character Dennis Kowalski
Stanley Townsend character Sheriff Weinbacher
Adi Shankar character John
Sam Spruell character Dave
Valerie Koch character Jerry's Mother
Gulliver McGrath character Jerry (12 years old)
Paul Brightwell character Jerry's Stepfather
Alessa Kordeck character Sheryl
Michael Pink character Jesus
Ricardia Bramley character Sheila Hammer
Alex Tondowski character Tom
