Johnny Depp character Raoul Duke
Benicio del Toro character Dr. Gonzo / Oscar Z. Acosta
Tobey Maguire character Hitchhiker
Christina Ricci character Lucy
Ellen Barkin character Waitress at North Star Cafe
Gary Busey character Highway Patrolman
Cameron Diaz character Blonde TV Reporter
Mark Harmon character Magazine Reporter at Mint 400
Katherine Helmond character Desk Clerk at Mint Hotel
Michael Jeter character Ron Bumquist
Penn Jillette character Carnie Talker
Craig Bierko character Lacerda
Lyle Lovett character Road Person
Laraine Newman character Frog-Eyed Woman
Harry Dean Stanton character Judge
Tim Thomerson character Hoodlum
Flea character Hippie/Musician
Christopher Meloni character Sven, Flamingo Hotel Clerk
Troy Evans character Police Chief
Debbie Reynolds character Herself (voice)
Jenette Goldstein character Alice the Maid
Verne Troyer character Wee Waiter
Gregory Itzin character Mint Hotel Clerk
Buck Holland character Shopper
Richard Riehle character Dune Buggy Driver
Mary Gillis character Shopper
Elenn Barkin character North Star Waitress
Hunter S. Thompson character Other Duke in Matrix Flashback (uncredited)
Richard Portnow character Wine Colored Tuxedo
Steve Schirripa character Goon
Larry Cedar character Car Rental Agent
Benjamin A. Van Der Veen character TV Crew Man
Alex Craig Mann character Stockbroker
Larry Brandenburg character Cop in Car
Michael Lee Gogin character Uniformed Dwarf
Brian Le Baron character Parking Attendant
Michael Warwick character Bell Boy
Tyde Kierney character Reporter
Ransom Gates character Dune Buggy Passenger
Frank Romano character Dune Buggy Passenger
Gil Boccaccio character Desert Room Doorman
Gary Bruno character Desert Room Doorman
Ben Yeagar character Clown Barker
Christopher Callen character Carnie Talker
Gale Baker character Police Chief's Wife
Chris Hendrie character Executive Director
Stephen Bridgewater character Human Cannonball
Donald Morrow character Voice of Drug Film Narrator (voice)
Jennifer Elise Cox character Shopper
Robert Allen character Car Rental Agent - Los Angeles
David Brisbin character Man in Car
James O'Sullivan character TV Newsman
Milt Tarver character TV Newsman
Kathryn Alexander character Lizard Performer
Mia Babalis character Lizard Performer
Kristin Draudt character Lizard Performer
Kim Flowers character Lizard Performer
Trudi Forristal character Lizard Performer
Nan Friedman character Lizard Performer
Judith Lieff character Lizard Performer
Tane McClure character Lizard Performer
Diana Mehoudar character Lizard Performer
Geoffrey Nimmer character Lizard Performer
Marlene Bologna character Trapeze Artist
Chobi Gyorgy character Trapeze Artist
Karen Price character Trapeze Artist
Lisa Hoyle character Trapeze Artist
Joseph S. Griffo character Trapeze Artist
