Jack Black character Brad Harris
Steve Martin character Stu Preissler
Owen Wilson character Kenny Bostick
John Cleese character Narrator (voice)
Rosamund Pike character Jessica Bostick
Kevin Pollak character Jim Gittelson
Joel McHale character Barry Loomis
Zahf Paroo character Prasad
Stacey Scowley character Vicki
Michael Karl Richards character Vicki's Fiancée
JoBeth Williams character Edith
Paul Campbell character Tony
Cindy Busby character Susie
Greg Kean character Computer Birder
Eva Bourne character Birder's Daughter
Bill Dow character Dr. Paul Elkin
Barry Shabaka Henley character Dr. Neil Kramer
Dianne Wiest character Brenda Harris
Brian Dennehy character Raymond Harris
Anthony Anderson character Bill Clemont
June Squibb character Old Lady
Craig Bockhorn character Lawyer
Jim Parsons character Crane
Anjelica Huston character Annie Auklet
Rashida Jones character Ellie
Tim Blake Nelson character Fuchs
Joey Aresco character Frank Falucci
Ryan Caltagirone character Frank Jr.
Al Roker character New York Weatherman
Christopher Mann character Security Guard
Jan Bos character Local Newsman (High Island)
Kate Gajdosik character Local Newswoman (High Island)
William Samples character British Tourist
Scott Patey character Birder (High Island)
Marci T. House character Troop Leader
Michael Bean character Waiter
Steven Weber character Rick
Christopher Redman character Scott
Devon Weigel character Karen
Andrew Wilson character Mike Shin
Gabrielle Rose character Mary Swit
Calum Worthy character Colin Debs
Terence Kelly character Pete Shackelford
David Lewis character Lanky Birder
Jesse Moss character Darren
Morgan Brayton character Ferry Ticket Seller
Corbin Bernsen character Gil
Sheelah Megill character Nurse
Nate Torrence character Ted Simkin
Veena Sood character Nurse Katie
Dee Jay Jackson character Parking Attendant
Calvin Lee character Chinese Waiter
