Robert Downey Jr. character Peter Highman
Michelle Monaghan character Sarah Highman
Zach Galifianakis character Ethan Tremblay
Jamie Foxx character Darryl
Juliette Lewis character Heidi
Todd Phillips character Barry
Charlie Sheen character Charlie Harper
Jon Cryer character Alan Harper
RZA character Airport Screener
Matt Walsh character TSA Agent
Danny McBride character Lonnie
Brody Stevens character Limo Driver
Jakob Ulrich character Patrick
Naiia Ulrich character Alex
Bobby Tisdale character Carl
Nathalie Fay character Flight Attendant
Sharon Conley character Airport X-Ray
Keegan-Michael Key character New Father
Paul Renteria character Border Guard
Emily Wagner character Flight Attendant
Steven M. Gagnon character Air Marshall
Marco Rodríguez character Federali Agent
Mimi Kennedy character Sarah's Mom
Tymberlee Hill character New Mother
Aaron Lustig character Dr. Greene
Haji Abdullah character Airport Passenger (uncredited)
Jeremy Ambler character TSA Agent (uncredited)
Madeline Brumby character Airport Pedestrian (uncredited)
Tony Folden character Construction Worker (uncredited)
Joseph Harold character Private Johnson (uncredited)
Sarah Reagin character Airport Security Agent (uncredited)
