Gwyneth Paltrow character Donna
Christina Applegate character Christine Montgomery
Mark Ruffalo character Ted Stewart
Candice Bergen character Sally Weston
Marc Blucas character Tommy Boulay
Kelly Preston character Sherry
Joshua Malina character Randy Jones
Stacey Dash character Angela Samona
Frederick Coffin character Mr. Stewart
Mike Myers character John Witney
Rob Lowe character Co-Pilot Steve Bench
Jon Polito character Roy Roby
Concetta Tomei character Mrs. Stewart
Robyn Peterson character Donna's Mom
Nadia Dajani character Paige
John Francis Daley character Rodney
Priscilla Inga Taylor character Janette
Matt Roth character Greg
Donna Marie Recco character Tammy
Daniel Raymont character British Man
Connie Sawyer character Grandma Stewart
David Hayward character Pete
Chelsey Cole character Donna - 6 Years Old
Troy Evans character Customer
Merrilee McCommas character June
George Kennedy character Passenger Requesting Vodka (uncredited)
Candice T. Cain character CDG Passenger (uncredited)
Valentin Siroon character Flight Attendant Trainee (uncredited)
Jessica Capshaw character Royalty International Flight Attendant
Mary McNeal character Ted's Study Partner Mary
Stephanie Miller character TV Interviewer
Susan Mosher character Senior Flight Attendant
Victoria Garcia-Kelleher character Clerk #1
Stephen Tobolowsky character Frank Thomas
Anastacia Spiegel character Runway Model at Airport
Amanda Wycoff character Flight Attendant Trainee
Dawn-Marie Whelan character Flight Attendant Trainee Anne
