Margot Robbie character Harleen Quinzel / Harley Quinn
Idris Elba character Robert DuBois / Bloodsport
John Cena character Christopher Smith / Peacemaker
Joel Kinnaman character Rick Flag
Sylvester Stallone character Nanaue / King Shark (voice)
Viola Davis character Amanda Waller
David Dastmalchian character Abner Krill / Polka-Dot Man
Daniela Melchior character Cleo Cazo / Ratcatcher 2
Peter Capaldi character Gaius Grieves / The Thinker
Michael Rooker character Brian Durlin / Savant
Jai Courtney character George 'Digger' Harkness / Captain Boomerang
Alice Braga character Sol Soria
Pete Davidson character Richard Hertz / Blackguard
Nathan Fillion character Cory Pitzner / T.D.K.
Storm Reid character Tyla DuBois
Joaquín Cosío character General Mateo Suarez
Juan Diego Botto character Silvio Luna
Steve Agee character John Economos / On-Set King Shark
Jennifer Holland character Emilia Harcourt
Tinashe Kajese character Flo Crawley
Sean Gunn character Weasel / Calendar Man
Flula Borg character Gunter Braun / Javelin
Mayling Ng character Mongal
Taika Waititi character Ratcatcher 1
Julio Ruiz character Milton
Lynne Ashe character Polka-Dot Man's Mom
Dee Bradley Baker character Sebastian (voice)
John Ostrander character Dr. Fitzgibbon
Stephen Blackehart character Briscoe
Natalia Safran character Kaleidoscope
Mikaela Hoover character Camila
Lloyd Kaufman character Man in Bar
Pom Klementieff character Dancer in Bar (uncredited)
Angel Airan Bonilla character Palace Guard
Andrew Ayala character Palace Guard (uncredited)
James William Ballard character Soldier (uncredited)
Timothy Carr character Prison Guard (uncredited)
Jared Leland Gore character Double Down
Gerardo Davila character General Vera
Josh Ventura character Astronaut
Giovannie Cruz character Isabella
Sergio Carlo character Isabella's Second
Edgar Zanabria character Torn-in-Half Soldado