Ben Stiller character Larry Daley
Amy Adams character Amelia Earhart
Owen Wilson character Jedediah Smith
Hank Azaria character Kahmunrah / The Thinker / Abe Lincoln
Robin Williams character Theodore Roosevelt
Christopher Guest character Ivan the Terrible
Alain Chabat character Napoleon Bonaparte
Steve Coogan character Octavius
Ricky Gervais character Dr. McPhee
Bill Hader character General George Armstrong Custer
Jon Bernthal character Al Capone
Patrick Gallagher character Attila the Hun
Jake Cherry character Nicky Daley
Rami Malek character Ahkmenrah
Mizuo Peck character Sacajawea
Kerry van der Griend character Neanderthal #1
Matthew Harrison character Neanderthal #2
Rick Dobran character Neanderthal #3
Randy Lee character Hun #1
Darryl Quon character Hun #2
Gerald Wong character Hun #3
Paul Chih-Ping Cheng character Hun #4
Jay Baruchel character Joey Motorola
Mindy Kaling character Docent
Keith Powell character Tuskegee Airman #1
Craig Robinson character Tuskegee Airman #2
Samuel Patrick Chu character Teenage Boy #1
Augustus Oicle character Teenage Boy #2
Kai James character Teenage Boy #3
Clint Howard character Air and Space Mission Control Tech #1
Matty Finochio character Air and Space Mission Control Tech #2
George Foreman character Himself
Josh Byer character Capone Gangster #1
Sophie Levy character Young Girl #1
Tess Levy character Young Girl #2
Christina Schild character 'American Gothic' Woman
Robert Thurston character 'American Gothic' Farmer
Alberta Mayne character Kissing Nurse
Clifton MaCabe Murray character Kissing Sailor
Caroll Spinney character Oscar the Grouch (voice)
Thomas Morley character Darth Vader
Dan Joffre character Town Car Driver
Dave Hospes character Astronaut
Regina Taufen character New York Reporter
Shawn Levy character Infomercial Father
Joe Jonas character Cherub #1 (voice)
Kevin Jonas character Cherub #2 (voice)
Nick Jonas character Cherub #3 (voice)
Eugene Levy character Albert Einstein Bobbleheads (voice)
Brad Garrett character Easter Island Head (voice)
Ed Helms character Larry Daley's Assistant (uncredited)
Jonah Hill character Brundon (uncredited)
Ben Garant character Orville Wright (uncredited)
Thomas Lennon character Wilbur Wright (uncredited)
Dan Savoie character NY Museum Patron (uncredited)
Frankie Jonas character Extra - Child in Museum (uncredited)
Don Abernathy character Airport Traveler (uncredited)
Dennis Albanese character Foreman (uncredited)
Aaron Atkins character Caveman (uncredited)
Tipper Burton character Museum Visitor (uncredited)
Hélène Cardona character Reporter (voice) (uncredited)
Lauren Emily Jacobs character School Girl (uncredited)
Waléra Kanischtscheff character Ivan the Terrible (voice) (uncredited)
Tom MacNeill character US Marine (uncredited)
Dan Martino character U.S. Solider (uncredited)
Douglas Nelson character Streltsy (uncredited)
Kennith Overbey character Tuskegee Airman (uncredited)
Robert Underwood character Air and Space Mission Control Tech (uncredited)