Nathan Fillion character Malcolm "Mal" Reynolds
Summer Glau character River Tam
Gina Torres character Zoë Alleyne Washburne
Alan Tudyk character Hoban "Wash" Washburne
Morena Baccarin character Inara Serra
Adam Baldwin character Jayne Cobb
Jewel Staite character Kaywinnet Lee "Kaylee" Frye
Sean Maher character Simon Tam
Ron Glass character Shepherd Derrial Book
Chiwetel Ejiofor character The Operative
David Krumholtz character Mr. Universe
Michael Hitchcock character Dr. Mathias
Sarah Paulson character Dr. Caron
Yan Feldman character Mingojerry "Mingo" Rample
Rafael Feldman character Fantastic "Fanty" Rample
Nectar Rose character Lenore
Tamara Taylor character Teacher
Glenn Howerton character Lilac Young Tough
Hunter Ansley Wryn character Young River Tam
Logan O'Brien character Boy Student
Erik Erotas character Boy Student
Demetra Raven character Girl Student
Marley McClean character Girl Student
Jessica Huang character Girl Student
Scott Kinworthy character Ensign
Erik Weiner character Helmsman
Conor O'Brien character Lab Technician
Peter James Smith character Lab Technician
Weston Nathanson character Trade Agent
Carrie 'CeCe' Cline character Young Female Intern
Chuck O'Neil character Vault Guard
Amy Wieczorek character Lilac Mom
Tristan Jarred character Lilac Son
Elaine Mani Lee character Fan Dancer
Terrence Hardy Jr. character Mining Camp Boy
Brian O'Hare character Alliance Pilot
Ryan Tasz character Black Room Soldier
Colin Patrick Lynch character Black Room Soldier
Terrell Tilford character News Anchor
Joshua Michael Kwiat character Slovenly Beaumonde Man
Antonio Rufino character Bartender (uncredited)
Linda Wang character Chinese Snake Dancer (uncredited)
Mark Winn character Furturistic Worker (uncredited)
Rick Williamson character Bar Guy (uncredited)
Neil Patrick Harris character Screaming Reaver (uncredited)
