Danny Trejo character Machete Cortez
Mel Gibson character Luther Voz
Demián Bichir character Mendez
Amber Heard character Blanca Vasquez / Miss San Antonio
Michelle Rodriguez character Luz
Sofía Vergara character Desdemona
Charlie Sheen character Mr. President
Jessica Alba character Sartana Rivera
Tom Savini character Osiris Amanpour
Vanessa Hudgens character Cereza Desdemona
Lady Gaga character La Camaleon
Cuba Gooding Jr. character El Camaleon
Antonio Banderas character El Camaleon
Walton Goggins character El Camaleon
William Sadler character Sheriff Doakes
Alexa PenaVega character KillJoy
Marko Zaror character Zaror
Julio Oscar Mechoso character Chepo
Billy Blair character Billy
Samuel Davis character Clebourne
Felix Sabates character Doc Felix
Electra Avellan character Nurse Mona
Elise Avellan character Nurse Lisa
Marci Madison character Nurse Fine
Callie Hernandez character Space Babe
Alejandro Antonio character Boss of Mendez
Crystal Martinez character Wife of Mendez
Corey Burton character Trailer Voice Guy (voice)
Elon Musk character Elon Musk
Bruce Campbell character Goon
Emmy Robbin character Pris
Jason Christopher character Lieutenant Brass
