Matthew Broderick character Despereaux (voice)
Dustin Hoffman character Roscuro (voice)
Emma Watson character Princess Pea (voice)
Tracey Ullman character Miggery Sow (voice)
Kevin Kline character Chef Andre (voice)
Sigourney Weaver character The Narrator (voice)
William H. Macy character Lester (voice)
Stanley Tucci character Boldo (voice)
Ciarán Hinds character Botticelli (voice)
Robbie Coltrane character Gregory (voice)
Tony Hale character Furlough (voice)
Frances Conroy character Antoinette (voice)
Frank Langella character Mayor (voice)
Richard Jenkins character Principal (voice)
Christopher Lloyd character Hovis (voice)
Charles Shaughnessy character Pietro (voice)
Patricia Cullen character Queen (voice)
McNally Sagal character Teacher (voice)
Sam Fell character Ned / Smudge (voice)