Steve Carell character David Sheff
Timothée Chalamet character Nicholas "Nic" Sheff
Maura Tierney character Karen Barbour
Amy Ryan character Vicki Sheff
Christian Convery character Jasper Sheff
Oakley Bull character Daisy Sheff
Kaitlyn Dever character Lauren
Stefanie Scott character Julia
Julian Works character Gack
Jack Dylan Grazer character 12-Year-Old Nic Sheff
Zachary Rifkin character 8-Year-Old Nic Sheff
Kue Lawrence character 4 & 6-Year-Old Nic Sheff
Timothy Hutton character Dr. Brown
Amy Forsyth character Diane
Andre Royo character Spencer
Mandeiya Flory character Kit
Ricky Low character Destiny
LisaGay Hamilton character Rose
Carlton Wilborn character Vince
David Mendenhall character Rocker (uncredited)
