Owen Wilson character Lightning McQueen (voice)
Larry the Cable Guy character Mater (voice)
Michael Caine character Finn McMissile (voice)
Emily Mortimer character Holley Shiftwell (voice)
John Turturro character Francesco Bernoulli (voice)
Eddie Izzard character Sir Miles Axlerod (voice)
Thomas Kretschmann character Professor Z (voice)
Guido Quaroni character Guido (voice)
Joe Mantegna character Grem (voice)
Peter Jacobson character Acer (voice)
Bruce Campbell character Rod "Torque" Redline (voice)
Tony Shalhoub character Luigi (voice)
Darrell Waltrip character Darrell Cartrip (voice)
Brent Musburger character Brent Mustangburger (voice)
Jason Isaacs character Siddeley / Leland Turbo (voice)
David Hobbs character David Hobbscap (voice)
Stanley Townsend character Victor Hugo / Vladimir Trunkov / Ivan the Tow Truck (voice)
Lloyd Sherr character Fillmore / Combat Ship (voice)
Paul Dooley character Sarge (voice)
Michel Michelis character Tomber (voice)
Sig Hansen character Crabby (voice)
Franco Nero character Uncle Topolino (voice)
Vanessa Redgrave character The Queen / Mama Topolino (voice)
Bonnie Hunt character Sally Carrera (voice)
Cheech Marin character Ramone (voice)
Jenifer Lewis character Flo (voice)
Michael Wallis character Sheriff (voice)
Katherine Helmond character Lizzie (voice)
John Ratzenberger character Mack (voice)
Jeff Garlin character Otis (voice)
Patrick Walker character Mel Dorado (voice)
Lewis Hamilton character Lewis Hamilton (voice)
Velibor Topic character Alexander Hugo (voice)
John Mainieri character J. Curby Gremlin (voice)
Brad Lewis character Tubbs Pacer (voice)
Richard Kind character Van (voice)
Edie McClurg character Minny (voice)
Teresa Gallagher character Mater's Computer (voice)
Jeff Gordon character Jeff Gorvette (voice)
John Lasseter character Additional Voices (voice)
Mark Winterbottom character Frosty (voice)
Daisuke 'Dice' Tsutsumi character Additional Voices (voice)
Fernando Alonso character Fernando Alonso (voice)
Vitaly Petrov character Vitaly Petrov (voice)
Jan Nilsson character Flash (voice)
Memo Rojas character Memo Rojas (voice)
Jacques Villeneuve character Jacques Villeneuve (voice)
Sebastian Vettel character Sebastian Vettel (voice)
Catherine Bolt character Additional Voices (voice)
Jess Fulton character Additional Voices (voice)
Sonoko Konishi character Additional Voices (voice)
Gillian Bolt character Additional Voices (voice)
