Matthew McConaughey character Ron Woodroof
Jared Leto character Rayon
Jennifer Garner character Dr. Eve Saks
Steve Zahn character Tucker
Denis O'Hare character Dr. Sevard
Dallas Roberts character David Wayne
Michael O'Neill character Richard Barkley
Kevin Rankin character T.J.
Griffin Dunne character Dr. Vass
J.D. Evermore character Clint
Donna DuPlantier character Nurse Frazin
James DuMont character Rayon's Father
Deneen Tyler character Denise
Ian Casselberry character Hispanic Orderly
Noelle Wilcox character Kelly
Bradford Cox character Sunny
Rick Espaillat character Michael
Lawrence Turner character Foreman
Lucius Falick character Freddie
Jane McNeill character Francine Suskind
Don Brady character Tucker's Father
Matthew Thompson character Effeminate Man
Tony Bentley character Judge
Sean Boyd character Border Agent
Rachel Wulff character News Anchor
Neeona Neal character Stripper
Scott Takeda character Mr. Yamata
Jonathan Tabler character Rick Ferris
Joji Yoshida character Dr. Hiroshi
Carl Palmer character FDA Customs Agent
Martin Covert character Ian
Douglas M. Griffin character Rog
David Lichtenstein character Cop
Craig Borten character Quicksilver Cowboy
Henry Frost character Gay Cowboy
Arthur Smith character Rodeo Announcer (voice)
Juliet Reeves London character Rodeo Girl (uncredited)
