Hugh Jackman character Tomás/Tom Creo/Tommy
Rachel Weisz character Queen Isabella/Izzi Creo
Ellen Burstyn character Dr. Lillian Guzetti
Mark Margolis character Father Avila
Stephen McHattie character Grand Inquisitor Silecio
Fernando Hernandez character Lord of Xibalba
Sean Patrick Thomas character Antonio
Donna Murphy character Betty
Ethan Suplee character Manny
Richard McMillan character Henry
Lorne Brass character Dr. Alan Lipper
Boyd Banks character Dominican Monk
Kevin Kelsall character Foot Soldier Rivera
Cliff Curtis character Captain Ariel
Abraham Aronofsky character Lab Technician
