Will Ferrell character Sherlock Holmes
John C. Reilly character Dr. John Watson
Rebecca Hall character Dr. Grace Hart
Ralph Fiennes character Prof. James Moriarty
Hugh Laurie character Mycroft Holmes
Kelly Macdonald character Mrs. Hudson
Steve Coogan character Gustav
Pam Ferris character Queen Victoria
Rob Brydon character Inspector Lestrade
Lauren Lapkus character Millie
Noah Jupe character Doxy
Bella Ramsey character Flotsam
Adam Scherr character Wrestler
Michael Culkin character Judge Over
Kieran O'Brien character PC Smalls
Jordan Long character Herbert
Jorge Leon Martinez character British Soldier
Billy Jenkins character Mudfog
Gerard Monaco character Officer
Scarlet Grace character Pickle
James Eeles character Manager Mr. Petrucka
Karl Farrer character Russian Merchant
Shawn Dixon character Upper Class Gentleman #1
Lindy Barrett character School Girl
Oliver Maltman character Telegraph Operator
Jason Thorpe character Butler
Martin Bassindale character One Man Band
Wolf Roth character Sigmund Freud
Ethan Rouse character Newsreader
Paddy Holland character Tough Kid
Willem Dalby character Newsie Man
Amelia O'Loughlin character White Star-Line Girl (uncredited)
Deepak Anand character Nobleman
Sonnyboy Skelton character Doxy's Dad
Hector Bateman-Harden character Young Sherlock Holmes
Paul T.T. Easter character John
Daniel Fearn character The Drooling Man
Phil Hodges character Mr. Algernon Barkworth
Paul Cassidy character Charlie Chaplin
Laura Stevely character Sherlock's Mother
John Kinory character Instructing Solicitor (uncredited)
Joseph Macnab character Fitness Instructor (uncredited)
Russell Wilcox character The Announcer
Craig Thomas Lambert character Yeoman of the guard
Lochlan White character Newsie Kid - Timmy
Riley White character Newsie Kid - Jimmy
Benjamin Lok character Courtroom Person 3
Jamie Baughan character Titanic Captain
Sara Beasley character Mrs. Frobisher
Henrihs Ahmadejevs character Drunk
David Handley character Executioner
Martyn Mayger character Buckingham Palace Guest
Codie-Lei Eastick character Young Watson
Anthony Richard Rowe character Victorian Gentleman
Samantha Sharon Watson character Elizabeth - Lady of the Night
David Shackleton character Albert Einstein
Matthew Di Liello character Telly-Phone Assistant
David Stoller character Guard (Southampton)
Colby Mulgrew character Haybag
Darren Lake character Disorientated Man
Mick Slaney character Docker (uncredited)
Wesley Kent-Hargreaves character The Weird Child
Ellie Rose Eames character Newschild
Stanley Eldridge character Waiter 2
Lilly Aspell character Urchin (uncredited)
Nick Davison character Upper Class Gentleman (uncredited)
Hugh O'Brien character Garden Party Guest (uncredited)
Andrew G. Ogleby character Lower Class Citizen (uncredited)
Richard Price character Grenadier Guard (uncredited)
Richard Price character Newsboy (uncredited)
Pete Freerunner Simpson character Police Officer (uncredited)
Bronson Webb character Jonathan Nightingale
Billy Zane character Himself
Michael Buffer character Fight Fan #1
Layla Rose Boyce character Nicotine Stains / Nancy
Sadie Newman character Jane
Harry Baxendale character Seamus
Ella Bright character Bridgette
Kenneth Hadley character Headmaster
Paul Bigley character Teacher #1
Sue Maund character Teacher #2
Tommy Surridge character Inky Hands
Billy Jenkins character Mud Fog
Jana Pérez character Lestrade's Wife
Nathan Osgood character Mark Twain
Jamie-Rose Monk character Mrs. Nightingale
Robert Cawsey character Waiter
Jack Riley character Newschild
Helen Duff character Titanic Guest
Jess Liaudin character Hangman
Martin Bishop character Priest
Bruce Buffer character Fight Fan #2
Patrick Holland character Tough Kid
Ben Lee character Houdini
