Robert Downey Jr. character Dr. John Dolittle
Antonio Banderas character King Rassouli
Michael Sheen character Dr. Blair Müdfly
Jim Broadbent character Lord Thomas Badgley
Jessie Buckley character Queen Victoria
Harry Collett character Tommy Stubbins
Emma Thompson character Poly (voice)
Rami Malek character Chee-Chee (voice)
John Cena character Yoshi (voice)
Kumail Nanjiani character Plimpton (voice)
Octavia Spencer character Dab-Dab (voice)
Tom Holland character Jip (voice)
Craig Robinson character Kevin (voice)
Ralph Fiennes character Barry (voice)
Selena Gomez character Betsy (voice)
Marion Cotillard character Tutu (voice)
Will Arnett character Jack Rabbit (voice) (uncredited)
Kasia Smutniak character Lily Dolittle
Carmel Laniado character Lady Rose
Frances de la Tour character Dragon (voice)
Jason Mantzoukas character James the Dragonfly (voice)
Ralph Ineson character Arnall Stubbins
Joanna Page character Bethan Stubbins
Sonny Ashbourne Serkis character Arnall Stubbins Jr.
Oliver Chris character Sir Gareth
Clive Francis character Archbishop
Paul Holowaty character Navy Man
Elliot Barnes-Worrell character Captain William Derrick
Mark Umbers character Lieutenant
David Sheinkopf character Don Carpenterino
Sid Sagar character Jeff the Prisoner
Martin Pemberton character Postman
Tim Treloar character Humphrey the Whale (voice)
Jim Carretta character Beard Mouse and Leona (voice)
Nick Fisher character Mini the Sugar Glider (voice)
Matt King character Clyde
Ranjani Brow character Mouse (voice)
Kelly Stables character Mouse (voice)
Scott Menville character Army Ant (voice)
Gia Davis character Baby Animal (voice)
Henry Holcomb character Baby Animal (voice)
Kyrie Mcalpin character Baby Animal (voice)
Isley Zamora character Baby Animal (voice)
Stewart Scudamore character Pirate
Samson Kayo character Pirate
John-Luke Roberts character Pirate / Animal Performer
Joseph Balderrama character Prisoner
Daniel Hoffmann-Gill character Prisoner
Jane Leaney character Animal Performer
Josh Jefferies character On Set Chee-Chee / Animal Performer
Shaun McKee character On Set Yoshi / Animal Performer
Richard Soames character Animal Performer
