Ryan Reynolds character Wade Wilson / Deadpool
Morena Baccarin character Vanessa Carlysle
Ed Skrein character Francis Freeman / Ajax
Gina Carano character Christina / Angel Dust
Karan Soni character Dopinder
Michael Benyaer character Warlord
Stefan Kapičić character Piotr Rasputin / Colossus (voice)
Brianna Hildebrand character Ellie Phimister / Negasonic Teenage Warhead
Style Dayne character Jeremy (Pizza Guy)
Kyle Cassie character Gavin Merchant
Taylor Hickson character Meghan Orlovsky
Ayzee character Teen Girl #1
Naika Toussaint character Teen Girl #2
Randal Reeder character Buck
T. J. Miller character Jack Hammer / Weasel
Isaac C. Singleton Jr. character Boothe
Justyn Shippelt character Arcade Ticket Taker
Donna Yamamoto character Oncologist
Jed Rees character Recruiter
Hugh Scott character David Cunningham
Cindy Piper character Chinatown Merchant
Emily Haine character Whisper Girlfriend
Aatash Amir character Whisper Boyfriend
Chad Riley character Pool Hall Goon
Paul Belsito character Fight Club Boss
Darcey Johnson character Garbage Truck Driver
Leslie Uggams character Blind Al
Kyle Rideout character Super Soldier #1
Jason William Day character Super Soldier #2
Ben Wilkinson character No5 Orange Manager
Rachel Sheen character Strip Club Worker
Paul Lazenby character Flight Deck Guard
Rob Hayter character Bob
Dan Zachary character Biker (uncredited)
Kayla Adams character Waitress Kelly (uncredited)
Heather Ashley Chase character Stripclub Pole Performer (uncredited)
Fabiola Colmenero character Guadalajaran Nurse (uncredited)
Victoria De Mare character Stripper (uncredited)
Jesse Michael Fullington character Guy in Strip Club (uncredited)
Tony Chris Kazoleas character Fight Club Spectator (uncredited)
Stan Lee character Strip Club Emcee (uncredited)
Rob Liefeld character Liefeld (uncredited)
David Longworth character Elderly Man (uncredited)
Sean Quan character Ten Year Old Boy (uncredited)
Anthony J Sacco character Thug #3 (uncredited)
Olesia Shewchuk character Guadalajaran Mother (uncredited)
Bronwyne Sloley character Fight Club Spectator (uncredited)
John Dryden character Thug #2 (uncredited)
