John Wayne character Thomas Dunson
Montgomery Clift character Matthew Garth
Joanne Dru character Tess Millay
Walter Brennan character 'Groot' Nadine
Coleen Gray character Fen
Harry Carey character Mr. Melville
John Ireland character Cherry Valance
Noah Beery Jr. character Buster McGee
Harry Carey, Jr. character Dan Latimer
Chief Yowlachie character Quo
Paul Fix character Teeler Yacey
Hank Worden character Simms Reeves
Mickey Kuhn character Matt, as a boy
Ray Hyke character Walt Jergens
Hal Taliaferro character Old Leather
Shelley Winters character Dance Hall Girl in Wagon Train (uncredited)
Lane Chandler character Colonel (uncredited)
Davison Clark character Mr. Meeker (uncredited)
Harry Cording character Gambler (uncredited)
Richard Farnsworth character Dunston Rider (uncredited)
Paul Fierro character Fernandez (uncredited)
George Lloyd character Rider with Melville (uncredited)
Pierce Lyden character Colonel's Trail Boss (uncredited)
Frank Meredith character Train Engineer (uncredited)
John Merton character Settler (uncredited) (uncredited)
Jack Montgomery character Drover at Meeting (uncredited)
Ivan Parry character Bunk Kenneally (uncredited)
Lee Phelps character Gambler (uncredited)
John Rice character Drover at Meeting (uncredited)
William Self character Sutter (uncredited)
Carl Sepulveda character Cowhand (uncredited)
Ray Spiker character Wagon Train Member (uncredited)
Glenn Strange character Naylor (uncredited)
Tom Tyler character Quitter (uncredited)
Dan White character Laredo (uncredited)
Guy Wilkerson character Pete (uncredited)