Ioan Gruffudd character Reed Richards / Mr. Fantastic
Jessica Alba character Sue Richards / Invisible Woman
Chris Evans character Johnny Storm / Human Torch
Michael Chiklis character Ben Grimm / The Thing
Julian McMahon character Victor von Doom / Doctor Doom
Kerry Washington character Alicia Masters
Andre Braugher character General Hager
Laurence Fishburne character Norrin Radd / Silver Surfer (voice)
Doug Jones character Norrin Radd / Silver Surfer
Beau Garrett character Frankie Raye
Brian Posehn character Priest
Zach Grenier character James Sherman / Rafke
Kenneth Welsh character Dr. Jeff Wagner
Kevin McNulty character Baxter Building Doorman
Andy Stahl character Tailor
Debbie Timuss character Hot Party Girl #1
Moneca Delain character Hot Party Girl #2
Crystal Lowe character Hot Party Girl #3
Vanessa Lachey character Johnny's Wedding Date
Stan Lee character Stan Lee - Rejected Wedding Guest
Gonzalo Menendez character Lieutenant
Giuliana Rancic character Entertainment Reporter
Lauren Sánchez character Fox News Reporter
Patricia Harras character Fan Four Receptionist
Fareed Abdelhak character Egyptian Tour Guide
Dawn Chubai character Anchorwoman
Alicia Thorgrimsson character New York Pedestrian
Valerie Tian character New York Teen Girl #1
Jeanna Haddow character New York Teen Girl #2
Ali Costigan character New York Teen Girl #3
Suzanne Ristic character Airline Woman
Michasha Armstrong character Wedding Security
Ulla Friis character Danish News Anchor (uncredited)
Tina Simmons character London Tourist (uncredited)
Nimet Kanji character Tourist in Egypt (uncredited)
