David Duchovny character Dr. Ira Kane
Julianne Moore character Dr. Allison Reed, CDC
Orlando Jones character Prof. Harry Phineas Block
Seann William Scott character Wayne Grey
Ted Levine character General Russell Woodman
Dan Aykroyd character Governor Lewis
Ty Burrell character Colonel Flemming
Andrew Bowen character Road Worker
Sarah Silverman character Denise
Katharine Towne character Nadine
Stephanie Hodge character Jill Mason
Gregory Itzin character Cartwright
Michelle Wolff character Carla
Steven Gilborn character Judge Guilder
Wayne Duvall character Dr. Paulson
Kyle Gass character Officer Drake
Jerry Trainor character Tommy
Jennifer Savidge character Clare
Wendy Braun character Nurse Tate
Michael Chapman character Sheriff Long
Ethan Suplee character Deke
Michael Bower character Danny
Mary Pat Gleason character Customer
John Cho character Student
Chris Wylde character Student
